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NCT03306732: APPLY
Thiamine Supplementation in High Risk Cardiac Surgery Patients
Phase 4 trial testing Thiamine hydrochloride (200mg) dissolved in 100 ml of normal saline in Cardiac Surgery in 40 participants. Completed in 18 June 2018.
18 May 2018
Quick facts
| Lead sponsor | Meshalkin Research Institute of Pathology of Circulation |
|---|---|
| Phase | Phase 4 |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | triple |
| Primary purpose | treatment |
| Enrollment | 40 |
| Start date | 19 October 2017 |
| Primary completion | 18 May 2018 |
| Estimated completion | 18 June 2018 |
| Sites | 1 location across Russia |
Drugs / interventions tested
- Thiamine hydrochloride (200mg) dissolved in 100 ml of normal saline — full drug profile →
- Normal saline (100ml) — full drug profile →
Conditions studied
- Cardiac Surgery — all drugs for Cardiac Surgery →
Sponsor
Meshalkin Research Institute of Pathology of Circulation
Who can join
18 and older, any sex, with Cardiac Surgery. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
This pilot trial will evaluate the ability of thiamine to affect on postoperative vasoplegia in high risk cardiac surgery patients
Publications & conference data
No peer-reviewed publications indexed yet for this trial. Completed trials usually publish results within 12-18 months.
Verify or expand the search:
- PubMed search for NCT03306732
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other recruiting trials for Cardiac Surgery
Currently open trials in the same condition.
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- NCT07417462 — Transversus Thoracic Muscle Plane Block Versus Pectointercostal Fascial Block for Enhanced Recovery After Cardiac Surger · NA · recruiting
- NCT07193719 — Influence of Personalized Lung Volume Optimization Maneuver on Lung Function and Cardiac Performance in Children · Phase 1, PHASE2 · recruiting
- NCT07116343 — Intrapleural Ropivacaine Infusion in Cardiac Surgery · Phase 4 · recruiting
- NCT07354841 — Safety and Performance Evaluation of CPB Venous and Arterial Cannulas · NA · recruiting
Other Meshalkin Research Institute of Pathology of Circulation trials
Trials by the same sponsor.
- NCT07372196 — Left Bundle Branch Pacing in Patients With Hypertrophic Cardiomyopathy After Myectomy · NA · recruiting
- NCT06443931 — Cryoablation of Intercostal Nerves for Pain Management in Early Postoperative Period in Patients With Minimally Invasive · NA · completed
- NCT06069115 — Radiotherapy Exposed Lung Injury: Effect on Functioning - Cohort · recruiting
- NCT05856461 — Pulmonary Artery Denervation in Patients With Atrial Fibrillation and Group 2 of Pulmonary Hypertension · NA · unknown
- NCT05643664 — The Role of Artificial Intelligence in the Treatment of Abdominal Aortic Aneurysms · NA · unknown
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT03306732 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Meshalkin Research Institute of Pathology of Circulation
- Last refreshed: 27 June 2018
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03306732.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing