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Normal saline (100ml)
Normal saline is an isotonic crystalloid solution that restores intravascular volume and maintains electrolyte balance.
Normal saline is an isotonic crystalloid solution that restores intravascular volume and maintains electrolyte balance. Used for Hypovolemia and fluid resuscitation, Maintenance of hydration in perioperative and critical care settings, Vehicle for intravenous medication administration.
At a glance
| Generic name | Normal saline (100ml) |
|---|---|
| Sponsor | Meshalkin Research Institute of Pathology of Circulation |
| Drug class | Crystalloid fluid / Electrolyte solution |
| Modality | Small molecule |
| Therapeutic area | General supportive care / Fluid and electrolyte management |
| Phase | FDA-approved |
Mechanism of action
Normal saline (0.9% sodium chloride in water) is a physiologic fluid replacement that mimics the osmolarity and electrolyte composition of blood plasma. It is used to restore circulating volume in hypovolemia, maintain hydration, and serve as a vehicle for intravenous medication delivery. The solution equilibrates across fluid compartments and is rapidly distributed throughout the body.
Approved indications
- Hypovolemia and fluid replacement
- Maintenance of hydration in perioperative and critical care settings
- Vehicle for intravenous medication administration
Common side effects
- Hyperchloremic acidosis
- Fluid overload / Pulmonary edema
- Hypernatremia
- Phlebitis at infusion site
Key clinical trials
- SMILE Trial - Imaging Sub-Study
- Comparison of the Effectiveness of Different Diuretic Therapies in the Management of Acute Heart Failure (NA)
- Bone Loss Prevention With Zoledronic Acid or Denosumab in Critically Ill Adults (PHASE2)
- Early Inflammatory-Immune Stratification and Precision Glucocorticoid Intervention in Acute Respiratory Failure Induced by Community-Acquired Pneumonia (PHASE1, PHASE2)
- Parenteral Ascorbic Acid Repletion in TransplantatIon (PHASE4)
- Efficacy of Early Argipressin in the Management of Intensive Care Patients With Norepinephrine-refractory Vasoplegic Shock (PHASE3)
- PANDORA: Delirium Prevention After Cardiac Surgery Using IV Acetaminophen to Prevent Postoperative Delirium in Older Cardiac Surgical Patients (PHASE3)
- HB-adMSCs vs Placebo for the Treatment of Juvenile Idiopathic Arthritis (PHASE2)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Normal saline (100ml) CI brief — competitive landscape report
- Normal saline (100ml) updates RSS · CI watch RSS
- Meshalkin Research Institute of Pathology of Circulation portfolio CI