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NCT03228030: THIAMINE-HF
Thiamine Supplementation in Heart Failure: a Pilot Randomized Controlled Crossover Trial
Phase 1 trial testing Thiamine in Heart Failure in 24 participants. Completed in 30 April 2021.
30 April 2021
Quick facts
| Lead sponsor | Hamilton Health Sciences Corporation |
|---|---|
| Phase | Phase 1 |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | crossover |
| Masking | quadruple |
| Primary purpose | treatment |
| Enrollment | 24 |
| Start date | 2 April 2018 |
| Primary completion | 30 April 2021 |
| Estimated completion | 30 April 2021 |
| Sites | 1 location across Canada |
Drugs / interventions tested
- Thiamine (THIAMINE) — full drug profile →
- Placebo
Conditions studied
- Heart Failure — all drugs for Heart Failure →
- Heart Failure With Reduced Ejection Fraction — all drugs for Heart Failure With Reduced Ejection Fraction →
- Thiamine Deficiency — all drugs for Thiamine Deficiency →
- Congestive Heart Failure — all drugs for Congestive Heart Failure →
Sponsor
Hamilton Health Sciences Corporation — full company profile →
Who can join
60 and older, any sex, with Heart Failure or Heart Failure With Reduced Ejection Fraction. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Heart failure (HF) is a major cardiovascular disease with increasing prevalence. Thiamine deficiency is common in HF patients. Previous small studies have shown that thiamine supplementation can improve left ventricular systolic function in HF, but larger clinical studies are lacking. Given the ease of supplementation and the potential benefits in HF, we aim to conduct a pilot randomized controlled trial (RCT) using high dose thiamine supplementation in HF patients. The main goal of this pilot study is to determine the feasibility of recruitment for an RCT of thiamine supplementation.
Publications & conference data
3 peer-reviewed publications reference this trial (live from Europe PMC):
-
The role of diet and nutrition in heart failure: A state-of-the-art narrative review.
Billingsley HE, Hummel SL, Carbone S. · · 2020 · cited 70× · PMID 32798501 · DOI 10.1016/j.pcad.2020.08.004 -
Thiamine versus placebo in older heart failure patients: study protocol for a randomized controlled crossover feasibility trial (THIAMINE-HF).
Wong EKC, Lee JY, Leong DP, Mbuagbaw L, et al · · 2018 · cited 8× · PMID 30258648 · DOI 10.1186/s40814-018-0342-0 -
High-Dose Thiamine Supplementation in Older Patients With Heart Failure: A Pilot Randomized Controlled Crossover Trial (THIAMINE-HF).
Wong EKC, Lee JY, Chow J, Power P, et al · · 2022 · cited 3× · PMID 35734514 · DOI 10.1016/j.cjco.2022.02.007
Verify or expand the search:
- PubMed search for NCT03228030
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other trials of Thiamine
Trials testing the same drug.
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- NCT06298344 — The Role of Thiamine After Transcatheter Closure in Children With Left-to-Right Shunt Congenital Heart Disease · EARLY_PHASE1 · completed
- NCT03509662 — Vitamin C in Post-cardiac Arrest · Phase 2 · completed
- NCT03634735 — Thiamin Against Robust IBD Fatigue · Phase 4 · completed
Other recruiting trials for Heart Failure
Currently open trials in the same condition.
- NCT06118983 — Improving TRansitions ANd OutcomeS for Heart FailurE Patients in Home Health CaRe (I-TRANSFER-HF) · NA · recruiting
- NCT07496372 — Efficacy and Safety of Human Induced Pluripotent Stem Cell-Derived Cardiomyocyte Injection (HiCM-188) in Advanced Heart · Phase 3 · recruiting
- NCT07527156 — Prolonged Nasogastric Administration of Ketones in Decompensated Heart Failure · Phase 4 · recruiting
- NCT07263035 — Urine Sodium-Driven Diuretic Adjustment Strategy in Acute Decompensated Heart Failure · Phase 4 · recruiting
- NCT07531966 — Vascular Complications After Kidney Transplantation · recruiting
Other Hamilton Health Sciences Corporation trials
Trials by the same sponsor.
- NCT06567808 — Prevention of Infections in Cardiac Surgery (PICS): a Cluster-randomized Factorial Cross-over Trial · Phase 4 · not yet recruiting
- NCT07118696 — Evaluating a Shorter, Rifampicin-Based Treatment for People With Less Severe Tuberculosis Disease · Phase 3 · not yet recruiting
- NCT07027436 — Radiation Therapy Followed by Durvalumab (MEDI4736) and Tremelimumab And Surgery Versus Radiation Therapy Followed by Su · Phase 3 · not yet recruiting
- NCT06908694 — Investigation of GLP1-Receptor Agonists in Men With Prostate Cancer Taking Androgen Deprivation Therapy · Phase 4 · recruiting
- NCT06836024 — A Trial of Actazin Versus PEG 3350 for Maintenance Therapy in Children With Constipation · Phase 2, PHASE3 · not yet recruiting
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT03228030 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Hamilton Health Sciences Corporation
- Last refreshed: 31 August 2021
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03228030.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing