NCT06326996 (B1&CABG) is a EARLY_PHASE1 clinical trial of Thiamine in Coronary Heart Disease, sponsored by University of California, Los Angeles.

Who is sponsoring NCT06326996?

NCT06326996 is sponsored by University of California, Los Angeles.

What drugs are being tested in NCT06326996?

Interventions in NCT06326996: Thiamine, Placebo.

What condition does NCT06326996 study?

NCT06326996 studies Coronary Heart Disease, Coronary Artery Bypass Grafting.

Is NCT06326996 still recruiting?

NCT06326996 is currently recruiting now. Last updated 1 August 2025.

Last reviewed 2025-08-01 · How we verify

NCT06326996: B1&CABG

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Thiamine Intervention and Coronary Artery Bypass Grafting

Recruiting now EARLY_PHASE1 Last updated 1 August 2025

What this trial tests

EARLY_PHASE1 trial testing Thiamine in Coronary Heart Disease in 52 participants. Currently enrolling.

Timeline

10 October 2024

Primary endpoint
30 June 2026

30 September 2026

Quick facts

Lead sponsor	University of California, Los Angeles
Phase	EARLY_PHASE1
Status	Recruiting now
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	single
Primary purpose	treatment
Enrollment	52
Start date	10 October 2024
Primary completion	30 June 2026
Estimated completion	30 September 2026
Sites	1 location across United States

Drugs / interventions tested

Thiamine (THIAMINE) — full drug profile →
Placebo

Conditions studied

Coronary Heart Disease — all drugs for Coronary Heart Disease →
Coronary Artery Bypass Grafting — all drugs for Coronary Artery Bypass Grafting →

Sponsor

University of California, Los Angeles

Who can join

Adults 60 to 80, any sex, with Coronary Heart Disease or Coronary Artery Bypass Grafting. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

The purpose of this study is to gain a better understanding of the association between brain changes and cognitive deficits in coronary heart disease (CHD) patients undergoing coronary artery bypass grafting (CABG) and whether a low-cost thiamine intervention can be used to reduce post-CABG cognitive issues in CHD subjects.

Publications & conference data

No peer-reviewed publications indexed yet for this trial.

Verify or expand the search:

Other trials of Thiamine

Trials testing the same drug.

NCT06322212 — Type 2 Diabetes and Blood Brain Barrier Improvement · EARLY_PHASE1 · recruiting
NCT06298344 — The Role of Thiamine After Transcatheter Closure in Children With Left-to-Right Shunt Congenital Heart Disease · EARLY_PHASE1 · completed
NCT03509662 — Vitamin C in Post-cardiac Arrest · Phase 2 · completed
NCT03634735 — Thiamin Against Robust IBD Fatigue · Phase 4 · completed
NCT04977557 — Thiamine in Patients With Clinically Suspected Dry Beriberi · NA · completed

Other recruiting trials for Coronary Heart Disease

Currently open trials in the same condition.

NCT07493603 — A Study on Yiyang Huoluo Decoction in the Treatment of Coronary Heart Disease · Phase 1, PHASE2 · recruiting
NCT07230847 — A Study Evaluating the Vascular Healing and Neointimal Transformation at 1 Month After Implantation of BioFreedom™ Drug- · NA · recruiting
NCT07110415 — Efficacy and Safety Trials of Yangxinshi Tablets in the Treatment of Patients With Coronary Heart Disease Complicated by · Phase 4 · recruiting
NCT07451873 — Glycocalyx and Oxidative Stress in Endothelial Function (Part 2) · recruiting
NCT07118930 — Study of Sivelestat Sodium in OPCABG · Phase 2 · recruiting

Other University of California, Los Angeles trials

Trials by the same sponsor.

NCT04846517 — rTMS for Aneroxia Nervosa in Youth · NA · not yet recruiting
NCT06701760 — Sodium Lactate in Severe TBI · Phase 2 · not yet recruiting
NCT04996667 — Effect of iNO in Patients With Submassive and Massive PE · Phase 2 · withdrawn
NCT05067387 — Evaluation of Oral THC and CBD in Men and Women · Phase 1 · not yet recruiting
NCT07534696 — Evaluation of Non-Invasive Pelvic Floor Neuromuscular Stimulation for Urinary Incontinence After Prostatectomy · NA · not yet recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT06326996 (US National Library of Medicine, public domain)
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by University of California, Los Angeles
Last refreshed: 1 August 2025

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT06326996.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing