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Thiamine Hydrochloride (THIAMINE)
Thiamine Hydrochloride (THIAMINE) is a thiamine (vitamin B1) small molecule developed by HOSPIRA, currently owned by the same company. It targets heat shock protein HSP 90-alpha and is FDA-approved since 1993 for various indications including cobalamin deficiency, Korsakoff's psychosis, and mineral deficiency prevention. THIAMINE is available as a generic medication with 20 manufacturers and is off-patent. Key safety considerations include its low bioavailability of 4%. It is used to treat various vitamin and mineral deficiencies.
At a glance
| Generic name | THIAMINE |
|---|---|
| Sponsor | Pfizer |
| Drug class | thiamine (vit B1) |
| Target | Heat shock protein HSP 90-alpha |
| Modality | Small molecule |
| Therapeutic area | Oncology |
| Phase | FDA-approved |
| First approval | 1993 |
Approved indications
- Cobalamin deficiency
- Korsakoff's psychosis
- Mineral Deficiency Prevention
- Mineral deficiency
- Pernicious anemia
- Prevention of Vitamin B12 Deficiency
- Thiamin deficiency
- Vitamin Deficiency Prevention
- Vitamin deficiency
Common side effects
- Hypersensitivity
- Anaphylactic reaction
- Collapse
- Death
- Pulmonary edema
- Hemorrhage into the gastrointestinal tract
- Angioneurotic edema
- Cyanosis
- Tenderness
- Induration
- Feeling of warmth
- Pruritus
Key clinical trials
- Safety, Tolerability and Pharmacokinetics of Benfo-Oxythiamine (B-OT) in Healthy Volunteers (PHASE1)
- Iron and Immune Response to Vaccine (IRONMUM) (NA)
- The Role of Thiamine After Transcatheter Closure in Children With Left-to-Right Shunt Congenital Heart Disease (EARLY_PHASE1)
- Synbiotic Supplement With Botanical Extracts for Gut Microbiota Balance in Irritable Bowel Syndrome (NA)
- Type 2 Diabetes and Blood Brain Barrier Improvement (EARLY_PHASE1)
- Clinical Trial On The Effect Of Artisterol On Risk Factors In Individuals With Suboptimal Cholesterol Levels (NA)
- Assessing the Impact of Herbal Supplement on Fatigue and Disease Activity in SLE: Results From an 8-Week Randomized Trial (NA)
- A Clinical Study to Evaluate the Efficacy of a Nutritional Supplement to Improve Carotenoid Content as Measured by a Non-invasive Hyperspectral Absorption Device (NA)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| FDA label | Mechanism, indications, dosing, boxed warnings, drug interactions |
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Thiamine Hydrochloride CI brief — competitive landscape report
- Thiamine Hydrochloride updates RSS · CI watch RSS
- Pfizer portfolio CI