Who is sponsoring NCT03209531?

NCT03209531 is sponsored by University of Michigan.

What drugs are being tested in NCT03209531?

Interventions in NCT03209531: Operant Conditioning, Control, Single Pulse Transcranial Magnetic Stimulation.

What condition does NCT03209531 study?

NCT03209531 studies Anterior Cruciate Ligament Injury.

Is NCT03209531 still recruiting?

NCT03209531 is currently completed. Last updated 26 November 2025.

Last reviewed 2025-11-26 · How we verify

NCT03209531

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Conditioning Brain Responses to Improve Thigh Muscle Function After Anterior Cruciate Ligament Reconstruction

Completed NA Last updated 26 November 2025

What this trial tests

NA trial testing Operant Conditioning in Anterior Cruciate Ligament Injury in 11 participants. Completed in 24 November 2025.

Timeline

21 September 2017

Primary endpoint
24 November 2025

24 November 2025

Quick facts

Lead sponsor	University of Michigan
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	none
Primary purpose	treatment
Enrollment	11
Start date	21 September 2017
Primary completion	24 November 2025
Estimated completion	24 November 2025
Sites	1 location across United States

Drugs / interventions tested

Operant Conditioning
Control
Single Pulse Transcranial Magnetic Stimulation

Conditions studied

Anterior Cruciate Ligament Injury — all drugs for Anterior Cruciate Ligament Injury →

Sponsor

University of Michigan

Who can join

Adults 18 to 45, any sex, with Anterior Cruciate Ligament Injury. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

The purpose of this study is to examine if thigh muscle weakness and the lack of muscle activation that accompanies ACL injury can be improved through a form of mental coaching and encouragement, known as operant conditioning.

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

Conditioning Brain Responses to Improve Quadriceps Function in an Individual With Anterior Cruciate Ligament Reconstruction.
Krishnan C, Washabaugh EP, Dutt-Mazumder A, Brown SR, et al · · 2019 · cited 16× · PMID 30951444 · DOI 10.1177/1941738119835163

Verify or expand the search:

Other trials of Operant Conditioning

Trials testing the same drug.

NCT05519345 — Operant Conditioning After ACL Reconstruction · NA · completed
NCT04286191 — Physiological Changes Induced Through MEP Conditioning in People With SCI · NA · completed

Other recruiting trials for Anterior Cruciate Ligament Injury

Currently open trials in the same condition.

NCT06357091 — ACL Reconstruction With Shark Screw® or Biocomposite-interference Screws · NA · recruiting
NCT05527171 — Virtual Reality Mindfulness Meditation After ACL Reconstruction · NA · recruiting
NCT03935750 — STABILITY 2: Anterior Cruciate Ligament Reconstruction +/- Lateral Tenodesis With Patellar vs Quad Tendon · NA · active not recruiting
NCT03348995 — The BEAR III Trial for Bridge-Enhanced ACL (Anterior Cruciate Ligament) Restoration · NA · active not recruiting

Other University of Michigan trials

Trials by the same sponsor.

NCT07536919 — Integrating Care for Hypertension-Diabetes MULTImorbidity in Guatemala Through HEARTS Implementation · NA · not yet recruiting
NCT05509842 — Function-based Accelerated Stimulation Therapy (FAST-therapy) for Freezing of Gait (FOG) After Parkinson's Disease (PD) · NA · not yet recruiting
NCT06311188 — Exploring PTSD Symptoms, Barriers and Facilitators to Mindfulness · NA · not yet recruiting
NCT07471646 — Effects of Ramadan Fasting With Exercise on Cardiometabolic Health · NA · not yet recruiting
NCT06671925 — A Community Health Worker-Led Program for Chronic Pain and Loneliness in Older Adults · NA · recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT03209531 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by University of Michigan
Last refreshed: 26 November 2025

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03209531.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing