NCT03176368

Coconut Oil: Managing Radiation-Induced Xerostomia

Status unknown NA Last updated 17 April 2018

What this trial tests

NA trial testing Coconut Oil in Xerostomia in 30 participants. Status unknown.

Timeline

5 October 2017

Primary endpoint
15 June 2018

15 September 2018

Quick facts

Lead sponsor	Ottawa Hospital Research Institute
Phase	NA
Status	Status unknown
Study type	INTERVENTIONAL
Allocation	na
Design	single group
Masking	none
Primary purpose	supportive care
Enrollment	30
Start date	5 October 2017
Primary completion	15 June 2018
Estimated completion	15 September 2018
Sites	1 location across Canada

Drugs / interventions tested

• Coconut Oil

Conditions studied

• Xerostomia — all drugs for Xerostomia →

Sponsor

Ottawa Hospital Research Institute

Who can join

18 and older, any sex, with Xerostomia. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

This study will seek to assess the experience of using of coconut oil as an approach to managing radiation-induced xerostomia in patients previously treated for cancer in the head and neck. There is a high prevalence of radiation-induced xerostomia in this patient population, and the condition has significant negative impact on patients' quality of life. There is currently no agreed-upon standard of care for the treatment of this condition. Anecdotal evidence from patients and both physicians and allied healthcare providers suggests improvement in this condition with the use of coconut oil, but this has not previously been formally studied. We therefore propose a case series study to formally assess the tolerability and efficacy of coconut oil as an approach to managing radiation-induced xerostomia.

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

1. Ionizing radiation: molecular mechanisms, biological effects, and therapeutic targets.
   Wei W, Ren Y, Lan J, Yi J, et al · · 2026 · PMID 41507636 · DOI 10.1186/s43556-025-00358-4