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NCT07464080: fMRI-TKA
Advanced Brain Imaging-TKA (fMRI-TKA)
NA trial testing fMRI Brain Scan in Knee Osteoarthritis (Knee OA) in 50 participants. Currently enrolling.
31 December 2027
Quick facts
| Lead sponsor | Ottawa Hospital Research Institute |
|---|---|
| Phase | NA |
| Status | Recruiting now |
| Study type | INTERVENTIONAL |
| Allocation | na |
| Design | single group |
| Masking | none |
| Primary purpose | treatment |
| Enrollment | 50 |
| Start date | 1 April 2026 |
| Primary completion | 31 December 2027 |
| Estimated completion | 31 December 2028 |
| Sites | 1 location across Canada |
Drugs / interventions tested
- fMRI Brain Scan
Conditions studied
- Knee Osteoarthritis (Knee OA) — all drugs for Knee Osteoarthritis (Knee OA) →
- Knee Pain Chronic — all drugs for Knee Pain Chronic →
- Brain Network Connectivity — all drugs for Brain Network Connectivity →
- Patient Satisfaction — all drugs for Patient Satisfaction →
Sponsor
Ottawa Hospital Research Institute
Who can join
18 and older, any sex, with Knee Osteoarthritis (Knee OA) or Knee Pain Chronic. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Knee replacement surgery is a common and effective treatment for pain and mobility loss, yet up to 1 in 5 patients remain dissatisfied after surgery due to ongoing pain or difficulty with daily activities. Currently, clinicians cannot reliably predict which patients will experience these challenges. This study uses MRI scan of the brain to investigate whether specific patterns of brain activity can predict patient satisfaction after total knee arthroplasty (TKA). By comparing brain networks before surgery and afterward, and linking these changes to patient-reported pain and function, we aim to identify brain-based markers that can help predict outcomes, to improve satisfaction after knee replacement surgery.
Publications & conference data
No peer-reviewed publications indexed yet for this trial.
Verify or expand the search:
- PubMed search for NCT07464080
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other recruiting trials for Knee Osteoarthritis (Knee OA)
Currently open trials in the same condition.
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- NCT07329023 — An Implementation Science Approach to Evaluating Self-Administered Acupressure for Knee Osteoarthritis in Older-Aged Adu · NA · recruiting
- NCT06845553 — A Study to Assess the Efficacy and Safety of Vutiglabridin in Knee Osteoarthritis Patients · Phase 2 · recruiting
- NCT07130630 — Validation and Reliability of the Vietnamese Pain Self-Efficacy Questionnaire in Knee Osteoarthritis · recruiting
- NCT07302724 — Drain Removal Before Versus After CPM in Primary Total Knee Arthroplasty · NA · active not recruiting
Other Ottawa Hospital Research Institute trials
Trials by the same sponsor.
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- NCT07177833 — Title Fractioned CO2 Laser in the Treatment of Chronic Phase Peyronie's Disease · Phase 1 · recruiting
- NCT06929767 — Do Blood Tests Help to Decide Which Patients With Flares of Chronic Obstructive Pulmonary Disease (COPD) Need Antibiotic · Phase 4 · not yet recruiting
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT07464080 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Ottawa Hospital Research Institute
- Last refreshed: 11 March 2026
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT07464080.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing