NCT03174301 (Pre-Vent) is a clinical trial in Infant, Premature, sponsored by University of Virginia.

Who is sponsoring NCT03174301?

NCT03174301 is sponsored by University of Virginia.

What condition does NCT03174301 study?

NCT03174301 studies Infant, Premature.

Is NCT03174301 still recruiting?

NCT03174301 is currently completed. Last updated 2 November 2022.

Last reviewed 2022-11-02 · How we verify

NCT03174301: Pre-Vent

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Prematurity-Related Ventilatory Control: Role in Respiratory Outcomes

Completed Last updated 2 November 2022

What this trial tests

trial in Infant, Premature in 739 participants. Completed in 4 June 2021.

Timeline

9 March 2018

Primary endpoint
4 June 2021

4 June 2021

Quick facts

Lead sponsor	University of Virginia
Status	Completed
Study type	OBSERVATIONAL
Enrollment	739
Start date	9 March 2018
Primary completion	4 June 2021
Estimated completion	4 June 2021
Sites	1 location across United States

Conditions studied

Infant, Premature — all drugs for Infant, Premature →

Sponsor

University of Virginia

Who can join

Under 1 Week, any sex, with Infant, Premature. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

The objective of this common multicenter protocol is to test the hypothesis that algorithmic tools using clinical Neonatal Intensive Care Unit (NICU) cardiorespiratory monitoring data can detect ventilatory control instability and predict chronic and acute respiratory consequences of ventilatory control instability and autonomic dysregulation.

Publications & conference data

8 peer-reviewed publications reference this trial (live from Europe PMC):

Cardiorespiratory Monitoring Data to Predict Respiratory Outcomes in Extremely Preterm Infants.
Ambalavanan N, Weese-Mayer DE, Hibbs AM, Claure N, et al · · 2023 · cited 39× · PMID 37219236 · DOI 10.1164/rccm.202210-1971oc
Maturation of cardioventilatory physiological trajectories in extremely preterm infants.
Weese-Mayer DE, Di Fiore JM, Lake DE, Hibbs AM, et al · · 2024 · cited 19× · PMID 37857848 · DOI 10.1038/s41390-023-02839-0
Apnea, Intermittent Hypoxemia, and Bradycardia Events Predict Late-Onset Sepsis in Infants Born Extremely Preterm.
Kausch SL, Lake DE, Di Fiore JM, Weese-Mayer DE, et al · · 2024 · cited 8× · PMID 38570031 · DOI 10.1016/j.jpeds.2024.114042
Highly comparative time series analysis of oxygen saturation and heart rate to predict respiratory outcomes in extremely preterm infants.
Qiu J, Di Fiore JM, Krishnamurthi N, Indic P, et al · · 2024 · cited 3× · PMID 38772400 · DOI 10.1088/1361-6579/ad4e91
Late permissive hypercapnia and respiratory stability among very preterm infants: a pilot randomised trial.
Travers CP, Carlo WA, Nakhmani A, Laney D, et al · · 2023 · cited 2× · PMID 36914233 · DOI 10.1136/archdischild-2022-325166
Necrotizing Enterocolitis: What's New and What's Next?
Sha C, Sander WR, Bass K, Hsieh H, et al · · 2025 · cited 1× · PMID 41096926 · DOI 10.3390/ijms26199660
Desaturations with or without Bradycardia Are Associated with Cerebral and Abdominal Hypoxemia: Secondary Analysis of a Randomized Clinical Trial.
Travers CP, Nakhmani A, Aban I, Laney D, et al · · 2026 · PMID 41615858 · DOI 10.1159/000550648
Control of breathing in preterm infants on incubator oxygen or nasal cannula oxygen.
Travers CP, Chahine R, Nakhmani A, Aban I, et al · · 2025 · PMID 39147903 · DOI 10.1038/s41390-024-03460-5

Verify or expand the search:

Other recruiting trials for Infant, Premature

Currently open trials in the same condition.

NCT07045402 — Effect of Developmental Care on Comfort, Growth, and Oral Feeding Transition in Preterm Infants · NA · recruiting
NCT06726226 — Extremely Preterm Respiratory Outcome Cohort · recruiting
NCT03456336 — Management of the PDA Trial · Phase 3 · active not recruiting
NCT02738411 — Influence of Intestinal Microbiota Implantation in Preterm Infants on Microbiota and Immune Orientation at 3 Years · active not recruiting
NCT00009633 — Follow-up Visit of High Risk Infants · recruiting

Other University of Virginia trials

Trials by the same sponsor.

NCT05880355 — Multimodality Cardiovascular Imaging for the Translation of Therapies for Vascular Activation After MI · EARLY_PHASE1 · not yet recruiting
NCT07405645 — Stereotactic MRI-guided Focused Ultrasound Mesencephalotomy · NA · recruiting
NCT07146685 — Effect of Local Anesthetic Concentration on Rebound Pain: A Randomized Control Study · Phase 4 · not yet recruiting
NCT07298941 — Resilience Enhancement Following Sleep Treatment · Phase 2 · recruiting
NCT07036315 — Meaning in Music-Based Pain Modulation · NA · recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT03174301 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by University of Virginia
Last refreshed: 2 November 2022

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03174301.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing