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NCT03114397
Long-term Effect of tDCS in Patients With Disorders of Consciousness
NA trial testing transcranial direct current stimulation - active in Disorder of Consciousness in 62 participants. Completed in 24 December 2021.
24 December 2021
Quick facts
| Lead sponsor | University of Liege |
|---|---|
| Phase | NA |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | triple |
| Primary purpose | treatment |
| Enrollment | 62 |
| Start date | 1 September 2017 |
| Primary completion | 24 December 2021 |
| Estimated completion | 24 December 2021 |
| Sites | 1 location across Belgium |
Drugs / interventions tested
- transcranial direct current stimulation - active
- transcranial direct current stimulation - sham
Conditions studied
- Disorder of Consciousness — all drugs for Disorder of Consciousness →
Sponsor
University of Liege
Who can join
Adults 16 to 80, any sex, with Disorder of Consciousness. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
In this multicentric double-blind sham controlled study, the investigators plan to assess the effects of 20 sessions of tDCS on long-term behavioral recovery in patients with disorders of consciousness. Neurophysiological outcomes (EEG) will also be collected. This research will 1) determine whether long-term behavioral recovery can be promoted with tDCS and 2) generate knowledge regarding the impact of tDCS on neurophysiological outcome (i.e., EEG) in severely brain injured patients. The investigators will compare the effects of active and sham tDCS on behavioral assessments and quantitative EEG in patients with severe brain injury and its potential application in rehabilitation.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
Noninvasive neuromodulation for disorders of consciousness: an updated systematic review and meta-analysis.
Gao Y, Bai J, Gu Z, Xie Y, et al · · 2025 · cited 1× · PMID 40611258 · DOI 10.1186/s13054-025-05429-0
Verify or expand the search:
- PubMed search for NCT03114397
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other recruiting trials for Disorder of Consciousness
Currently open trials in the same condition.
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- NCT06469983 — Robotic vs. Traditional Verticalization in Patients With Severe Acquired Brain Injury: a Randomized Controlled Trial · NA · recruiting
- NCT06527573 — Effects of rTMS With Different Stimulation Spots in Patients With Disorders of Consciousness · NA · recruiting
- NCT06635291 — Improving the Diagnostic Accuracy of Children with DoC (IDeAl DesiRE) · recruiting
Other University of Liege trials
Trials by the same sponsor.
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- NCT07331779 — Effect of tDCS Timing on Motor Recovery in Acute Stroke Rehabilitation · NA · not yet recruiting
- NCT07237893 — Impact of a Physical Activity Intervention on Cardiometabolic Health, Mental Health, and Lifestyle Factors. · NA · not yet recruiting
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT03114397 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by University of Liege
- Last refreshed: 3 November 2022
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03114397.
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