NCT06964282

Iliopsoas (IPB) and Pericapsular Nerve Group (PENG) Blocks Comparison on Analgesia and Recovery After Total Hip Arthroplasty

Not yet recruiting NA Last updated 15 May 2025

What this trial tests

NA trial testing PENG Block in Total Hip Arthroplasty (THA) in 118 participants. Not yet recruiting.

Timeline

1 October 2025

Primary endpoint
1 October 2026

10 October 2026

Quick facts

Lead sponsor	University of Liege
Phase	NA
Status	Not yet recruiting
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	quadruple
Primary purpose	treatment
Enrollment	118
Start date	1 October 2025
Primary completion	1 October 2026
Estimated completion	10 October 2026
Sites	1 location across Belgium

Drugs / interventions tested

• PENG Block — full drug profile →
• Iliopsoas nerve block — full drug profile →

Conditions studied

• Total Hip Arthroplasty (THA) — all drugs for Total Hip Arthroplasty (THA) →
• Postoperative Pain Management — all drugs for Postoperative Pain Management →
• Peripheral Nerve Blocks — all drugs for Peripheral Nerve Blocks →
• PENG Block — all drugs for PENG Block →

Sponsor

University of Liege

Who can join

18 and older, any sex, with Total Hip Arthroplasty (THA) or Postoperative Pain Management. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Background:

In recent years, regional anesthesia has become more popular because it can reduce pain and the need for strong pain medications like morphine. For hip surgery, the PENG block is already known to be effective. A newer method, called the iliopsoas plane block (IPB), is very similar and has also shown good results in hip arthroscopy. However, these two techniques have never been directly compared in patients undergoing hip replacement surgery using the posterior approach.

Goal:

This study aims to see if the IPB is just as effective as the PENG block for controlling pain and helping patients recover well after hip replacement surgery.

Method:

118 adult patients scheduled for hip replacement under spinal anesthesia will be randomly assigned to receive either: IPB: 7 ml of Ropivacaine 7.5 mg/ml PENG: 14 ml of Ropivacaine 3.75 mg/ml Both injections are given under ultrasound guidance 30 minutes before spinal anesthesia. Neither the patient, the surgeon, nor the data collector will know which technique was used.

Post-Surgery Care:

All patients will receive standard pain relief, including:

Paracetamol every 6 hours Etoricoxib once a day Morphine via a patient-controlled pump for 48 hours

Main Outcome Measured:

The primary goal is to compare pain during movement 6 hours after surgery, using a pain scale from 0 (no pain) to 10 (worst pain). The study will consider the two blocks equivalent if the difference in average pain scores is less than 1 point.

Other Outcomes:

Total morphine used in 48 hours Pain scores at rest and during movement at various time points Walking ability (2- and 6-minute walk tests, and timed-up-and-go test) Quality of recovery (using the QoR-15 questionnaire) Side effects of morphine Patient satisfaction Length of hospital stay

Safety:

Both techniques are safe and already used in clinical practice. Ultrasound guidance minimizes risks like nerve injury, bleeding, or infection.

Conclusion:

If the IPB is shown to be as effective as the PENG block, both can be considered reliable options for pain control and early recovery after hip replacement surgery.

Publications & conference data

No peer-reviewed publications indexed yet for this trial.