Last reviewed · How we verify
NCT03107000
Corneal Endothelial Cell Loss After Trabeculectomy Versus Phakotrabeculectomy
NA trial testing Trabeculectomy in Corneal Endothelial Cell Loss in 25 participants. Completed in 14 October 2022.
30 June 2021
Quick facts
| Lead sponsor | Sunnybrook Health Sciences Centre |
|---|---|
| Phase | NA |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | non randomized |
| Design | parallel |
| Masking | none |
| Primary purpose | diagnostic |
| Enrollment | 25 |
| Start date | 1 September 2017 |
| Primary completion | 30 June 2021 |
| Estimated completion | 14 October 2022 |
| Sites | 1 location across Canada |
Drugs / interventions tested
- Trabeculectomy
- Phako-trabeculectomy
Conditions studied
- Corneal Endothelial Cell Loss — all drugs for Corneal Endothelial Cell Loss →
- Glaucoma — all drugs for Glaucoma →
Sponsor
Sunnybrook Health Sciences Centre — full company profile →
Who can join
18 and older, any sex, with Corneal Endothelial Cell Loss or Glaucoma. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Corneal endothelial cells health and pumping function is crucial to permit corneal optical clarity by keeping cornea in relatively dehydrated state. Corneal endothelial damage has been associated with most types of intraocular surgery. Trabeculectomy is the standard glaucoma surgical intervention in management of progressive glaucoma despite of medical therapy which can be performed in combination with Cataract surgery (Phacoemulsification and IOL implantation) in patients with cataract-impaired visual acuity. In this study, the investigators will investigate and compare the corneal endothelial cells number and health status before and after trabeculectomy vs. combined surgery (at 1 month and 3 months post-op visits) using Specular microscopy which is a non-invasive technique to access the structure and function of the corneal endothelium by permitting visualization of the corneal endothelial mosaic to assess the effect of this surgical intervention on corneal endothelial cells health and number.
Publications & conference data
No peer-reviewed publications indexed yet for this trial. Completed trials usually publish results within 12-18 months.
Verify or expand the search:
- PubMed search for NCT03107000
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other trials of Trabeculectomy
Trials testing the same drug.
- NCT07152132 — SCTSC Versus Trabeculectomy in Medically Uncontrolled Open-Angle Glaucoma in Pseudophakic Patients · NA · recruiting
- NCT05163951 — Trabeculectomy Versus Peripheral Iridectomy Plus Goniotomy in Advanced PACG · NA · recruiting
- NCT04727411 — Analysis of Conjunctival Changes as Indicators for Ab-interno Gelatin Microstent Implantation Surgery Outcomes · NA · completed
- NCT04647929 — Comparison of Surgical Treatment Options for Primary Congenital and Developmental Glaucomas · NA · withdrawn
- NCT04440527 — Intraocular Pressure After Preserflo / Innfocus Microshunt Implantation vs Trabeculectomy · NA · unknown
Other recruiting trials for Corneal Endothelial Cell Loss
Currently open trials in the same condition.
- NCT05847387 — The Viability Control of Human Endothelial Cells Before Keratoplasty (V-CHECK) Study · recruiting
Other Sunnybrook Health Sciences Centre trials
Trials by the same sponsor.
- NCT07478705 — Early Detection of Metastatic Recurrence Among Patients With Stage II or III Triple Negative Breast Cancer Using Liquid · NA · not yet recruiting
- NCT07376018 — Ketogenic Diet and Neuromodulation in Treatment Resistant Depression · NA · not yet recruiting
- NCT07350278 — Comparing Virtual Reality Simulation to High Fidelity Simulation as an Educational Modality for Electroconvulsive Therap · NA · not yet recruiting
- NCT07191145 — Eary Infusion of Eptinezumab for TreatmEnt of ACute Post-Traumatic Headaches (ELITE-ACT) · Phase 3 · not yet recruiting
- NCT07308587 — Evaluation of Intercostal Neuralgia in Patients With Chest Tube Insertion After Traumatic Rib Fracture · not yet recruiting
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT03107000 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Sunnybrook Health Sciences Centre
- Last refreshed: 13 April 2023
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03107000.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing