NCT05163951 (TVG) is a NA clinical trial of Trabeculectomy in Primary Angle Closure Glaucoma, sponsored by Sun Yat-sen University.

Who is sponsoring NCT05163951?

NCT05163951 is sponsored by Sun Yat-sen University.

What drugs are being tested in NCT05163951?

Interventions in NCT05163951: Trabeculectomy, SPI+GSL+GT.

What condition does NCT05163951 study?

NCT05163951 studies Primary Angle Closure Glaucoma.

Is NCT05163951 still recruiting?

NCT05163951 is currently recruiting now. Last updated 14 June 2022.

Last reviewed 2022-06-14 · How we verify

NCT05163951: TVG

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Trabeculectomy Versus Peripheral Iridectomy Plus Goniotomy in Advanced PACG

Recruiting now NA Last updated 14 June 2022

What this trial tests

NA trial testing Trabeculectomy in Primary Angle Closure Glaucoma in 88 participants. Currently enrolling.

Timeline

5 January 2022

Primary endpoint
30 June 2024

30 June 2026

Quick facts

Lead sponsor	Sun Yat-sen University
Phase	NA
Status	Recruiting now
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	none
Primary purpose	treatment
Enrollment	88
Start date	5 January 2022
Primary completion	30 June 2024
Estimated completion	30 June 2026
Sites	1 location across China

Drugs / interventions tested

Trabeculectomy
SPI+GSL+GT

Conditions studied

Primary Angle Closure Glaucoma — all drugs for Primary Angle Closure Glaucoma →

Sponsor

Sun Yat-sen University

Who can join

Adults 45 to 80, any sex, with Primary Angle Closure Glaucoma. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

A multicenter, parallel, open, non-inferior randomized controlled trial is conducted to compare the effectiveness and safety of trabeculectomy and peripheral iridectomy plus goniotomy (TVG) in the treatment of advanced primary angle closure glaucoma with no or mild cataracts.

Publications & conference data

3 peer-reviewed publications reference this trial (live from Europe PMC):

Efficacy and safety of trabeculectomy versus peripheral iridectomy plus goniotomy in advanced primary angle-closure glaucoma: study protocol for a multicentre, non-inferiority, randomised controlled trial (the TVG study).
Gao X, Lv A, Lin F, Lu P, et al · · 2022 · cited 9× · PMID 35788072 · DOI 10.1136/bmjopen-2022-062441
Peripheral Iridectomy With Goniosynechialysis and Goniotomy vs Trabeculectomy for Advanced PACG: A Randomized Clinical Trial.
Lin F, Lv A, Li F, Song Y, et al · · 2025 · cited 2× · PMID 40244579 · DOI 10.1001/jamaophthalmol.2025.0757
Characteristics and publication status of minimally invasive glaucoma surgery trials registered in ClinicalTrials.gov, 2007-2024: a cross-sectional study.
Peng C, Jia H, Hu J, Jiao Y. · · 2025 · PMID 39855651 · DOI 10.1136/bmjopen-2024-095854

Verify or expand the search:

Other trials of Trabeculectomy

Trials testing the same drug.

NCT07152132 — SCTSC Versus Trabeculectomy in Medically Uncontrolled Open-Angle Glaucoma in Pseudophakic Patients · NA · recruiting
NCT04727411 — Analysis of Conjunctival Changes as Indicators for Ab-interno Gelatin Microstent Implantation Surgery Outcomes · NA · completed
NCT04647929 — Comparison of Surgical Treatment Options for Primary Congenital and Developmental Glaucomas · NA · withdrawn
NCT04440527 — Intraocular Pressure After Preserflo / Innfocus Microshunt Implantation vs Trabeculectomy · NA · unknown
NCT04333433 — PRESERFLO® MicroShunt Extension Study · completed

Other recruiting trials for Primary Angle Closure Glaucoma

Currently open trials in the same condition.

NCT06952153 — Comparison of Phaco Surgery With Goniosynechialysis Versus Trabeculectomy in Glaucoma Treatment · NA · recruiting

Other Sun Yat-sen University trials

Trials by the same sponsor.

NCT07255612 — Bone Marrow Protection, Safety, Efficacy of Trilaciclib and Eribulin in Locally Advanced or Metastatic TNBC(Triple-negat · Phase 2 · not yet recruiting
NCT07371897 — Toripalimab ± Chemo as Neoadjuvant Therapy in LA-HNSCC: A Phase III Trial · Phase 3 · not yet recruiting
NCT07489703 — SHR-A1811 + AK112 in HER2-Altered Advanced/Metastatic NSCLC · Phase 2 · not yet recruiting
NCT07528209 — Neoadjuvant CAPOX With or Without Pucotenlimab Plus Selective Radiotherapy for Locally Advanced Rectal Cancer · Phase 3 · recruiting
NCT07522281 — Evaluation of an Undisturbed Embryo Culture System for Embryo Development in IVF/ICSI Cycles · NA · not yet recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT05163951 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Sun Yat-sen University
Last refreshed: 14 June 2022

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05163951.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing