NCT03087604 is a Phase 4 clinical trial of Thoracic epidural block in Anesthesia, sponsored by Wake Forest University Health Sciences.

Who is sponsoring NCT03087604?

NCT03087604 is sponsored by Wake Forest University Health Sciences.

What drugs are being tested in NCT03087604?

Interventions in NCT03087604: Thoracic epidural block, Electrical Nerve stimulation, Solution For Thoracic epidural block.

What condition does NCT03087604 study?

NCT03087604 studies Anesthesia.

Is NCT03087604 still recruiting?

NCT03087604 is currently completed. Last updated 17 June 2020.

Are results published for NCT03087604?

Yes — primary outcome results have been posted to ClinicalTrials.gov. See the outcomes section above for details.

Last reviewed 2020-06-17 · How we verify

NCT03087604

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Loss of Resistance, w/wo Stimulation, For Epidural Placement

Completed Phase 4 Results posted Last updated 17 June 2020

What this trial tests

Phase 4 trial testing Thoracic epidural block in Anesthesia in 100 participants. Completed in 11 October 2017.

Timeline

17 March 2017

Primary endpoint
11 October 2017

11 October 2017

Quick facts

Lead sponsor	Wake Forest University Health Sciences
Phase	Phase 4
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	double
Primary purpose	supportive care
Enrollment	100
Start date	17 March 2017
Primary completion	11 October 2017
Estimated completion	11 October 2017
Sites	1 location across United States

Drugs / interventions tested

Thoracic epidural block — full drug profile →
Electrical Nerve stimulation
Solution For Thoracic epidural block — full drug profile →

Conditions studied

Anesthesia — all drugs for Anesthesia →

Sponsor

Wake Forest University Health Sciences

Who can join

Adults 18 to 90, any sex, with Anesthesia. Patients with the condition only — healthy volunteers not accepted.

Results — posted to ClinicalTrials.gov

Per-arm endpoint measurements with 95% confidence intervals where reported. Source: trial results section.

Success Rate of Placement of a Thoracic Epidural Primary · 15 minutes after administration of a test dose of lidocaine

will be determined by the detection of a loss of sensation to cold (ice) in at least two contiguous dermatomal levels, 15 minutes after administration of a test dose of lidocaine through the epidural catheter. If a loss of cold sensation is found, then the epidural placement will be classified as successful. If no loss of cold sensation is found, then the epidural placement will be classified as unsuccessful.

Group	Value	95% CI
Traditional Technique Group	41
Electric Stimulation Group	45

Time Required to Place the Epidural Catheter Secondary · From the initiation of procedure to end of procedure

The time required to place the epidural catheter will be recorded

Group	Value	95% CI
Traditional Technique Group	33.9	± 12.8
Electric Stimulation Group	24.0	± 8.0

Sponsor's own description

The purpose of this randomized, observer-blinded, investigative trial is to determine if the use of electrical stimulation, compared to the traditional loss of resistance technique alone, improves the success rate of epidural catheter placement at an academic teaching institution.

Publications & conference data

2 peer-reviewed publications reference this trial (live from Europe PMC):

A randomized comparison of loss of resistance versus loss of resistance plus electrical stimulation: effect on success of thoracic epidural placement.
Dobson SW, Weller RS, Edwards C, Turner JD, et al · · 2022 · cited 5× · PMID 35139802 · DOI 10.1186/s12871-022-01584-x
A Randomized Comparison of Loss of Resistance Versus Loss of Resistance Plus Electrical Stimulation: Effect On Success of Thoracic Epidural Placement
Dobson SW, Weller RS, Edwards C, Turner JD, et al · · 2021 · DOI 10.21203/rs.3.rs-544222/v1

Verify or expand the search:

Other trials of Thoracic epidural block

Trials testing the same drug.

NCT06974643 — Thoracic Epidural Anesthesia Versus Paravertebral Block for Awake Thoracotomy · NA · recruiting
NCT06884852 — Ultrasound-guided Multilevel Erectorspinae Plane Block Versus Thoracic Epidural Analgesia for Prevention of Post Mastect · NA · recruiting
NCT03677856 — The Effectiveness of ThOracic Epidural and Paravertebral Blockade In Reducing Chronic Post- Thoracotomy Pain: 2 · NA · unknown
NCT04541732 — Postoperative Analgesia of Quadratus Lumborum Block Versus Epidural Block After Major Abdominal Surgeries · NA · completed

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Currently open trials in the same condition.

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Other Wake Forest University Health Sciences trials

Trials by the same sponsor.

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NCT06876896 — Intra-abdominal Pressure (IAP) During PFA Treatment of A-fib/ A-Flutter · NA · recruiting
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Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT03087604 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Wake Forest University Health Sciences
Last refreshed: 17 June 2020

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03087604.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing