NCT03041428 (UPV-ECMO) is a NA clinical trial of Ultraprotective ventilation in Cardiogenic Pulmonary Edema, sponsored by Fundación para la Investigación Biosanitaria del Principado de Asturias.

Who is sponsoring NCT03041428?

NCT03041428 is sponsored by Fundación para la Investigación Biosanitaria del Principado de Asturias.

What drugs are being tested in NCT03041428?

Interventions in NCT03041428: Ultraprotective ventilation.

What condition does NCT03041428 study?

NCT03041428 studies Cardiogenic Pulmonary Edema, Ventilator-Induced Lung Injury, Extracorporeal Circulation; Complications.

Is NCT03041428 still recruiting?

NCT03041428 is currently completed. Last updated 1 April 2021.

Last reviewed 2021-04-01 · How we verify

NCT03041428: UPV-ECMO

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Ultra Protective Ventilation During Venoarterial Extracorporeal Membrane Oxygenation (UPV-ECMO)

Completed NA Last updated 1 April 2021

What this trial tests

NA trial testing Ultraprotective ventilation in Cardiogenic Pulmonary Edema in 20 participants. Completed in 1 March 2021.

Timeline

1 February 2017

Primary endpoint
31 December 2019

1 March 2021

Quick facts

Lead sponsor	Fundación para la Investigación Biosanitaria del Principado de Asturias
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	na
Design	single group
Masking	none
Primary purpose	supportive care
Enrollment	20
Start date	1 February 2017
Primary completion	31 December 2019
Estimated completion	1 March 2021
Sites	1 location across Spain

Drugs / interventions tested

Ultraprotective ventilation

Conditions studied

Cardiogenic Pulmonary Edema — all drugs for Cardiogenic Pulmonary Edema →
Ventilator-Induced Lung Injury — all drugs for Ventilator-Induced Lung Injury →
Extracorporeal Circulation; Complications — all drugs for Extracorporeal Circulation; Complications →

Sponsor

Fundación para la Investigación Biosanitaria del Principado de Asturias

Who can join

18 and older, any sex, with Cardiogenic Pulmonary Edema or Ventilator-Induced Lung Injury. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Mechanical ventilation, in spite of being a life-saving technique, can also induce lung injury (VILI) mediated by an inflammatory response, thus having a profound impact in the course of critically ill patients. Ventilatory strategies aimed to minimize this VILI have reduced mortality rates. Patients suffering cardiogenic pulmonary edema may need venoarterial extracorporeal oxygenation, at the same time they are being mechanically ventilated. The objective of this study is to analyze changes induced by the use of utraprotective ventilatory strategies in the inflammatory lung response of these patients and their impact on outcomes.

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

Biotrauma during ultra-low tidal volume ventilation and venoarterial extracorporeal membrane oxygenation in cardiogenic shock: a randomized crossover clinical trial.
Amado-Rodríguez L, Del Busto C, López-Alonso I, Parra D, et al · · 2021 · cited 10× · PMID 34453620 · DOI 10.1186/s13613-021-00919-0

Verify or expand the search:

Other Fundación para la Investigación Biosanitaria del Principado de Asturias trials

Trials by the same sponsor.

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NCT05311254 — A Trial of Fosfomycin vs Ciprofloxacin for Febrile Neutropenia · Phase 3 · unknown
NCT04838938 — Personalized Medicine in Patients With Infective Endocarditis · completed
NCT04660448 — Lung Ultrasound Score and Pediatric Intensive Care Outcomes (LUS-PICO) · completed

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT03041428 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Fundación para la Investigación Biosanitaria del Principado de Asturias
Last refreshed: 1 April 2021

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03041428.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing