NCT02995291 is a Phase 4 clinical trial of OraVerse in Anesthesia, Local, sponsored by Dalhousie University.

Who is sponsoring NCT02995291?

NCT02995291 is sponsored by Dalhousie University.

What drugs are being tested in NCT02995291?

Interventions in NCT02995291: OraVerse, Saline Water (Control).

What condition does NCT02995291 study?

NCT02995291 studies Anesthesia, Local.

Is NCT02995291 still recruiting?

NCT02995291 is currently completed. Last updated 29 January 2020.

Last reviewed 2020-01-29 · How we verify

NCT02995291

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Reversing the Effects of 0.5% Bupivacaine

Completed Phase 4 Last updated 29 January 2020

What this trial tests

Phase 4 trial testing OraVerse in Anesthesia, Local in 44 participants. Completed in 15 September 2019.

Timeline

10 February 2017

Primary endpoint
15 May 2019

15 September 2019

Quick facts

Lead sponsor	Dalhousie University
Phase	Phase 4
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	quadruple
Primary purpose	treatment
Enrollment	44
Start date	10 February 2017
Primary completion	15 May 2019
Estimated completion	15 September 2019
Sites	1 location across Canada

Drugs / interventions tested

OraVerse — full drug profile →
Saline Water (Control) — full drug profile →

Conditions studied

Anesthesia, Local — all drugs for Anesthesia, Local →

Sponsor

Dalhousie University

Who can join

18 and older, any sex, with Anesthesia, Local. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Clinical trials have shown phentolamine mesylate (PM), brand name OraVerse, to be effective at reducing the amount of time to reversal of local anesthesia with different dental anesthetics. However, to date no study investigated the efficacy of phentolamine mesylate to reverse anesthesia induced with the use of Bupivacaine. The objective of the proposed research is to conduct a pilot-scale randomized clinical trial evaluating the difference in time required for the return of normal soft-tissue sensation and function in participants who have received 0.5% Bupivacaine HCl, 1:200,000 epinephrine, followed by an injection with either 1) OraVerse (phentolamine mesylate) or 2) sterile physiological water (control).

Publications & conference data

No peer-reviewed publications indexed yet for this trial. Completed trials usually publish results within 12-18 months.

Verify or expand the search:

Other recruiting trials for Anesthesia, Local

Currently open trials in the same condition.

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NCT06694714 — Split Face Study of the Duration of Local Anesthetics - Fourth Arm · Phase 4 · recruiting
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NCT06528288 — Effects of Erector Spinae Plane Block on Postoperative Pain Following Lumbar Fusion Surgery · NA · recruiting

Other Dalhousie University trials

Trials by the same sponsor.

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NCT06777277 — Cognitive-Behavioural Couple Therapy for Sexual Interest/Arousal Disorder · NA · recruiting
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NCT06588049 — Nitrate Mouth Rinse and the Oral Microbiome · NA · completed

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT02995291 (US National Library of Medicine, public domain)
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Dalhousie University
Last refreshed: 29 January 2020

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT02995291.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing