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NCT02910206: EPIC
Etomidate to Improve Outcome in Elderly Patients
NA trial testing Etomidate in Postoperative Complications in 1,917 participants. Completed in 20 November 2020.
20 November 2019
Quick facts
| Lead sponsor | Zhihong LU |
|---|---|
| Phase | NA |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | triple |
| Primary purpose | treatment |
| Enrollment | 1,917 |
| Start date | 15 August 2017 |
| Primary completion | 20 November 2019 |
| Estimated completion | 20 November 2020 |
| Sites | 1 location across China |
Drugs / interventions tested
- Etomidate (ETOMIDATE) — full drug profile →
- propofol (Propofol) — full drug profile →
- Sufentanil (SUFENTANIL) — full drug profile →
- Cisatracurium (CISATRACURIUM) — full drug profile →
Conditions studied
- Postoperative Complications — all drugs for Postoperative Complications →
Sponsor
Zhihong LU — full company profile →
Who can join
Adults 65 to 80, any sex, with Postoperative Complications. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Elderly patients have high mortality and postoperative complications rate after surgery, especially postoperative cardiac complications. A meta-analysis revealed haemodynamic intraoperative events significantly increased the risk of postoperative cardiac complications.To limit the risk, optimize the intraoperative management of circulation is essential. Anesthetic drug may effect on the haemodynamic intraoperative, reduction of postoperative complications should aimed at choosing the optimal anesthetic drug with minimal effect on haemodynamic.So this study is to explore the comparative efficacy and safety of anesthetic drug (etomidate or propofol) in elderly patients
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
Effect of Etomidate vs Propofol for Total Intravenous Anesthesia on Major Postoperative Complications in Older Patients: A Randomized Clinical Trial.
Lu Z, Zheng H, Chen Z, Xu S, et al · · 2022 · cited 31× · PMID 35947398 · DOI 10.1001/jamasurg.2022.3338
Verify or expand the search:
- PubMed search for NCT02910206
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other trials of Etomidate
Trials testing the same drug.
- NCT04291521 — Prospective Study of Induction Medications Used in the Trauma RSI · not yet recruiting
- NCT07012902 — Relationship Between Remimazolam and Etomidate in Induction of General Anesthesia · EARLY_PHASE1 · not yet recruiting
- NCT06664138 — Comparison of Remimazolam and Etomidate As Induction Agents for Electroconvulsive Treatment · Phase 4 · completed
- NCT05277896 — Randomized Trial of Sedative Choice for Intubation · Phase 4 · completed
- NCT04934410 — Induction Agent and Incidence of Hypotension in Heart Failure Patients Undergoing LVAD-Implantation · unknown
Other recruiting trials for Postoperative Complications
Currently open trials in the same condition.
- NCT07428057 — Postoperative Hypocalcemia After Thyroidectomy · recruiting
- NCT07401173 — DeepComp for Prediction of Gastric Cancer Postoperative Complications (DeepComp-Prospective) · recruiting
- NCT07388108 — Atrial Dyssynchrony to Predict Arrhythmias in the Postoperative Setting of Cardiovascular Surgery. · recruiting
- NCT07375602 — A Multimodal AI Prediction Model for Complications After Transcatheter Closure of Perimembranous VSD in Children · recruiting
- NCT07349719 — Dynamic Compliance-Guided Ventilation in Lumbar Surgery · NA · recruiting
Other Zhihong LU trials
Trials by the same sponsor.
- NCT07440121 — Optimized Strict Fluid Management Helps Improve Endpoints After Liver Dissection · NA · not yet recruiting
- NCT07445399 — Drawing Therapy for pReoperative Anxiety in Waiting (DRAW) · NA · not yet recruiting
- NCT07433218 — Frequency of Electrical Acupoint Stimulation on Hypotension During Induction · NA · not yet recruiting
- NCT06521632 — Acupoint Stimulation Improves Cognition Under Hypoxia · NA · not yet recruiting
- NCT06161662 — STimulation Electronically of Acupoints for Postoperative Delirium in elderlY Patients · NA · completed
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT02910206 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Zhihong LU
- Last refreshed: 10 December 2020
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT02910206.
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