NCT02891564

ESTIA: Computerized Intervention Targeting Cognitive Control Deficits in Depressed Adults

Completed NA Last updated 21 December 2022

What this trial tests

NA trial testing Band Together in Major Depression in 79 participants. Completed in 20 January 2022.

Timeline

2 January 2019

Primary endpoint
20 January 2022

20 January 2022

Quick facts

Lead sponsor	University of Washington
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	single group
Masking	single
Primary purpose	treatment
Enrollment	79
Start date	2 January 2019
Primary completion	20 January 2022
Estimated completion	20 January 2022
Sites	2 locations across United States

Drugs / interventions tested

• Band Together
• Control Mobile 3D video game

Conditions studied

• Major Depression — all drugs for Major Depression →

Sponsor

University of Washington

Who can join

Adults 45 to 75, any sex, with Major Depression. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Project:EVO is a video-game based intervention that targets neural networks associated with cognitive control. The same networks have been implicated in poor treatment response in middle and older aged adults suffering from major depression. Related work has demonstrated that healthy older adults show significant improvement in cognitive control. In a very small sample of older adults suffering from depression (n=12), we found similar improvements in selective attention and working memory after 4 weeks of intervention, along with improvements in mood comparable to participants receiving an evidence-based psychotherapy. The intent of this proposal is to first determine if at least 2/3 of participants who use Project:EVO for four weeks demonstrate significant improvements in the function of these neural networks, and if improvements are observed, to conduct a second study to see if changes in neural network functions are associated with changes in mood. If we show that Project:EVO improves neural function and mood to a greater degree than a placebo cognitive training game, we will be in a position to move onto the next phase of study, which is to demonstrate the intervention's efficacy in a much larger sample of adults with depression.

Publications & conference data

No peer-reviewed publications indexed yet for this trial. Completed trials usually publish results within 12-18 months.