NCT02874131 is a NA clinical trial of Behavioral Activation in Posttraumatic Stress Disorder, sponsored by United States Naval Medical Center, San Diego.

Who is sponsoring NCT02874131?

NCT02874131 is sponsored by United States Naval Medical Center, San Diego.

What condition does NCT02874131 study?

NCT02874131 studies Posttraumatic Stress Disorder, Major Depressive Disorder.

Is NCT02874131 still recruiting?

NCT02874131 is currently completed. Last updated 15 November 2024.

Last reviewed 2024-11-15 · How we verify

NCT02874131

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Behavioral Activation + Cognitive Processing Therapy for PTSD and Comorbid MDD

Completed NA Last updated 15 November 2024

What this trial tests

NA trial testing Behavioral Activation in Posttraumatic Stress Disorder in 100 participants. Completed in 18 March 2022.

Timeline

20 October 2015

Primary endpoint
18 March 2022

18 March 2022

Quick facts

Lead sponsor	United States Naval Medical Center, San Diego
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	single
Primary purpose	treatment
Enrollment	100
Start date	20 October 2015
Primary completion	18 March 2022
Estimated completion	18 March 2022
Sites	1 location across United States

Drugs / interventions tested

Behavioral Activation
Cognitive Processing Therapy

Conditions studied

Posttraumatic Stress Disorder — all drugs for Posttraumatic Stress Disorder →
Major Depressive Disorder — all drugs for Major Depressive Disorder →

Sponsor

United States Naval Medical Center, San Diego

Who can join

18 and older, any sex, with Posttraumatic Stress Disorder or Major Depressive Disorder. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

This study is a randomized controlled trial comparing an integrated treatment, Behavioral Activation + Cognitive Processing Therapy (BA + CPT), to CPT alone among active-duty service members with posttraumatic stress disorder (PTSD) and comorbid major depressive disorder (MDD). Participants will complete assessor-administered and self-report measures at pre- and post-treatment assessments, as well as a 3-month follow-up. Additionally, participants will complete self-report measures of PTSD and MDD symptoms at each therapy session.

Publications & conference data

3 peer-reviewed publications reference this trial (live from Europe PMC):

Dropout in a clinical trial for comorbid PTSD and MDD among US service members: Are pretreatment characteristics predictive?
Kline AC, Otis NP, Norman SB, Hunt WM, et al · · 2025 · cited 2× · PMID 38497740 · DOI 10.1080/10503307.2024.2325519
Sudden gains in cognitive processing therapy with and without behavioral activation among service members with comorbid PTSD and MDD.
Otis NP, Kline AC, Glassman LH, Michael Hunt W, et al · · 2025 · cited 1× · PMID 40288269 · DOI 10.1016/j.brat.2025.104753
Sex differences in treatment outcomes among U.S. service members with comorbid PTSD and MDD.
Glassman LH, Otis NP, Kline AC, Hunt WM, et al · · 2026 · PMID 41620779 · DOI 10.1186/s40359-025-03878-4

Verify or expand the search:

Other trials of Behavioral Activation

Trials testing the same drug.

NCT06696001 — Neuroscience of Psychotherapy for Depression · NA · recruiting
NCT06796608 — Behavioral Activation-Led Activity Engagement for Cancer Empowerment · NA · completed
NCT06273995 — Telehealth Behavioral Activation for Teens · NA · recruiting
NCT05685511 — Behavioral Activation and Medication Optimization For Improving Perioperative Mental Health In Older Adults Undergoing O · NA · completed
NCT05574127 — A Study of Brief Behavioral Activation for the Treatment of Depression in Older Adult Cancer Survivors · Phase 2 · active not recruiting

Other United States Naval Medical Center, San Diego trials

Trials by the same sponsor.

NCT06536114 — Efficacy of a Criteria Based Clinical Pathway for Rehabilitation of Shoulder Injuries · NA · not yet recruiting
NCT06044714 — Effects of Acupuncture on Perceived Stress and Health in Military Service Members · NA · completed
NCT06413173 — Remotely Supervised tDCS+ for Complex Attention in mTBI (Cognetric) · NA · recruiting
NCT05795764 — Crisis Response Planning for Military Personnel · NA · recruiting
NCT04607356 — Blood Flow Restriction Exercise in the Treatment of Lateral Epicondylalgia Traditional Treatment · NA · unknown

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT02874131 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by United States Naval Medical Center, San Diego
Last refreshed: 15 November 2024

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT02874131.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing