NCT02744495 (PONVACS) is a Phase 3 clinical trial of Betamethasone in Postoperative Vomiting, sponsored by Hôpital Privé de Parly II - Le Chesnay.

Who is sponsoring NCT02744495?

NCT02744495 is sponsored by Hôpital Privé de Parly II - Le Chesnay.

What drugs are being tested in NCT02744495?

Interventions in NCT02744495: Betamethasone, Droperidol.

What condition does NCT02744495 study?

NCT02744495 studies Postoperative Vomiting, Postoperative Nausea, Postoperative Emesis.

Is NCT02744495 still recruiting?

NCT02744495 is currently completed. Last updated 13 December 2016.

Last reviewed 2016-12-13 · How we verify

NCT02744495: PONVACS

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Prophylaxis of Postoperative Nausea and Vomiting After Cardiac Surgery (PONVACS)

Completed Phase 3 Last updated 13 December 2016

What this trial tests

Phase 3 trial testing Betamethasone in Postoperative Vomiting in 502 participants. Completed in 1 December 2016.

Timeline

1 February 2016

Primary endpoint
1 November 2016

1 December 2016

Quick facts

Lead sponsor	Hôpital Privé de Parly II - Le Chesnay
Phase	Phase 3
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	none
Primary purpose	prevention
Enrollment	502
Start date	1 February 2016
Primary completion	1 November 2016
Estimated completion	1 December 2016
Sites	1 location across France

Drugs / interventions tested

Betamethasone (BETAMETHASONE) — full drug profile →
Droperidol (DROPERIDOL) — full drug profile →

Conditions studied

Postoperative Vomiting — all drugs for Postoperative Vomiting →
Postoperative Nausea — all drugs for Postoperative Nausea →
Postoperative Emesis — all drugs for Postoperative Emesis →

Sponsor

Hôpital Privé de Parly II - Le Chesnay

Who can join

18 and older, any sex, with Postoperative Vomiting or Postoperative Nausea. Patients with the condition only — healthy volunteers not accepted.

What's being measured

Primary outcomes are the specific endpoints the trial is designed to prove or disprove.

postoperative nausea and vomiting
Time frame: 48hour
postoperative nausea and vomiting as a categorical variable

Sponsor's own description

To investigate the role of postoperative nausea and vomiting risk factors assessment after cardiac surgery. We designed a randomized controlled study comparing standard care (no risk factor assessment and no intervention) with prophylaxis of postoperative nausea and vomiting after cardiac surgery in high risk patients. Prophylaxis of postoperative nausea and vomiting by betamethasone (4mg) and/or droperidol (0.625mg) immediately after cardiac surgery, depending on risk factors (if risk score is over 2) in the intervention arm.

Publications & conference data

2 peer-reviewed publications reference this trial (live from Europe PMC):

Drugs for preventing postoperative nausea and vomiting in adults after general anaesthesia: a network meta-analysis.
Weibel S, Rücker G, Eberhart LH, Pace NL, et al · · 2020 · cited 125× · PMID 33075160 · DOI 10.1002/14651858.cd012859.pub2
Prophylaxis of postoperative nausea and vomiting after cardiac surgery in high-risk patients: A randomized controlled study.
Champion S, Zieger L, Hemery C. · · 2018 · cited 21× · PMID 29336385 · DOI 10.4103/aca.aca_122_17

Verify or expand the search:

Other trials of Betamethasone

Trials testing the same drug.

NCT06786689 — To Compare the Efficacy of Weekly Azathioprine Pulse Versus Betamethasone Oral Mini-Pulse in the Treatment of Moderate t · Phase 2 · completed
NCT07297264 — Betamethasone and Complications of Lower Third Molar Surgery · Phase 3 · terminated
NCT04900220 — Differences in Flare Reaction Incidence and Intensity Following Trigger Finger Injections · Phase 4 · completed
NCT03210545 — A Study of Markers of Glucocorticoid Effects in Patients With Addisons Disease (DOSCORT) · Phase 4 · completed
NCT03702959 — Antenatal Betamethasone and the Risk of Neonatal Hypoglycemia · unknown

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT02744495 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Hôpital Privé de Parly II - Le Chesnay
Last refreshed: 13 December 2016

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT02744495.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing