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NCT02248493: IVPARACET
The Effect of Intravenous Paracetamol in Combination With NSAIDs for Postoperative Pain in Children
Phase 4 trial testing Paracetamol in Pain, Postoperative in 54 participants. Completed in 1 March 2017.
1 March 2017
Quick facts
| Lead sponsor | Lithuanian University of Health Sciences |
|---|---|
| Phase | Phase 4 |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | triple |
| Primary purpose | treatment |
| Enrollment | 54 |
| Start date | 1 November 2012 |
| Primary completion | 1 March 2017 |
| Estimated completion | 1 March 2017 |
| Sites | 1 location across Lithuania |
Drugs / interventions tested
- Paracetamol (Paracetamol) — full drug profile →
- Placebo (for paracetamol) — full drug profile →
- Ketoprofen (KETOPROFEN) — full drug profile →
- Tramadol (tramadol) — full drug profile →
- Morphine
Conditions studied
- Pain, Postoperative — all drugs for Pain, Postoperative →
- Recovery of Function — all drugs for Recovery of Function →
- Child — all drugs for Child →
Sponsor
Lithuanian University of Health Sciences
Who can join
Adults 1 to 18, any sex, with Pain, Postoperative or Recovery of Function. Patients with the condition only — healthy volunteers not accepted.
What's being measured
Primary outcomes are the specific endpoints the trial is designed to prove or disprove.
-
change in postoperative intravenous opioid dose
Time frame: 24 hours postoperatively
Sponsor's own description
The purpose of this study is to define if intravenous paracetamol may improve analgesia and outcome in pediatric surgical patients treated with non-steroidal anti-inflammatory drugs (NSAIDs) postoperatively. Hypothesis: intravenous paracetamol in a dose 60 mg/kg/24 h IV, given in addition to IV ketoprofen (4,5 mg/kg/24h), improves analgesia and physical recovery in children and adolescents following surgery.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
Intravenous Paracetamol in Adjunct to Intravenous Ketoprofen for Postoperative Pain in Children Undergoing General Surgery: A Double-Blinded Randomized Study.
Rugytė D, Gudaitytė J. · · 2019 · cited 7× · PMID 30939851 · DOI 10.3390/medicina55040086
Verify or expand the search:
- PubMed search for NCT02248493
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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Other Lithuanian University of Health Sciences trials
Trials by the same sponsor.
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT02248493 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Lithuanian University of Health Sciences
- Last refreshed: 3 March 2017
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT02248493.
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