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Placebo (for paracetamol)
A placebo produces therapeutic effects through psychological and psychophysiological mechanisms, including expectation, conditioning, and natural disease course.
A placebo produces therapeutic effects through psychological and psychophysiological mechanisms, including expectation, conditioning, and natural disease course. Used for Comparator control in paracetamol efficacy studies.
At a glance
| Generic name | Placebo (for paracetamol) |
|---|---|
| Also known as | 0.9% sodium cloride solution, Normal saline solution, Izotonic saline solution |
| Sponsor | Lithuanian University of Health Sciences |
| Modality | Small molecule |
| Therapeutic area | General/Comparative Research |
| Phase | FDA-approved |
Mechanism of action
Placebos are inert substances that can elicit measurable clinical improvements in certain conditions through the patient's expectation of benefit and activation of endogenous healing mechanisms. The placebo effect involves both conscious psychological processes and unconscious physiological responses, including changes in neurotransmitter release, immune function, and pain perception. In this context, it is being studied as a comparator for paracetamol efficacy evaluation.
Approved indications
- Comparator control in paracetamol efficacy studies
Common side effects
- Nocebo effects (adverse events attributed to placebo)
Key clinical trials
- Evaluation of Broccoli Seed and Sprout Extract for Detoxification of Carcinogens in Firefighters (PHASE2)
- Jaw Muscle Pain Post Wisdom Molar Surgery (PHASE2)
- Prophylactic Treatment of the Ductus Arteriosus in Preterm Infants by Acetaminophen (PHASE2, PHASE3)
- Open-label Placebo (COLP) for Pain in Adolescent Idiopathic Scoliosis (AIS) Surgery+Surgical Treatment of Idiopathic Scoliosis (NA)
- High-dose Prophylactic Gabapentin (HOPE) vs. Placebo to Prevent Opioid Use for Oral Mucositis Pain During Concurrent Chemoradiation for Head and Neck Cancer (PHASE3)
- Analgesic Efficacy and Obstetric Effects of Tramadol, Paracetamol and Placebo in Active Labor (PHASE4)
- Randomized Controlled Trial of CES for Fibromyalgia (NA)
- PARASTOP - Paracetamol With Strong Opioids (PHASE3)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Placebo (for paracetamol) CI brief — competitive landscape report
- Placebo (for paracetamol) updates RSS · CI watch RSS
- Lithuanian University of Health Sciences portfolio CI