NCT01937767 is a Phase 2 clinical trial of Remimazolam in General Anesthesia, sponsored by Paion UK Ltd..

Who is sponsoring NCT01937767?

NCT01937767 is sponsored by Paion UK Ltd..

What drugs are being tested in NCT01937767?

Interventions in NCT01937767: Remimazolam, Propofol, Sevoflurane, Remifentanil, Fentanyl, Rocuronium.

What condition does NCT01937767 study?

NCT01937767 studies General Anesthesia.

Is NCT01937767 still recruiting?

NCT01937767 is currently completed. Last updated 15 January 2020.

Last reviewed 2020-01-15 · How we verify

NCT01937767

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

A Randomized, Single-blind Phase II Study Evaluating the Efficacy, Safety and Pharmacokinetics of Remimazolam in General Anesthesia in Adult Patients Undergoing Cardiac Surgery, Including Follow-up Sedation in the PACU/ICU

Completed Phase 2 Last updated 15 January 2020

What this trial tests

Phase 2 trial testing Remimazolam in General Anesthesia in 90 participants. Completed in 19 February 2014.

Timeline

1 August 2013

Primary endpoint
1 February 2014

19 February 2014

Quick facts

Lead sponsor	Paion UK Ltd.
Phase	Phase 2
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	single
Primary purpose	treatment
Enrollment	90
Start date	1 August 2013
Primary completion	1 February 2014
Estimated completion	19 February 2014
Sites	1 location across Germany

Drugs / interventions tested

Remimazolam
Propofol (Propofol) — full drug profile →
Sevoflurane — full drug profile →
Remifentanil
Fentanyl (fentanyl) — full drug profile →
Rocuronium (ROCURONIUM) — full drug profile →

Conditions studied

General Anesthesia — all drugs for General Anesthesia →

Sponsor

Paion UK Ltd. — full company profile →

Who can join

18 and older, any sex, with General Anesthesia. Patients with the condition only — healthy volunteers not accepted.

What's being measured

Primary outcomes are the specific endpoints the trial is designed to prove or disprove.

Proportion of patients with successful anesthesia
Time frame: Between the start of study medication and the end of the surgical procedure (up to approx 12 hours)
Successful anesthesia was defined as no use of rescue sedative medication between start of the study medication and end of the surgical procedure completion of last skin suture.

Sponsor's own description

This phase II study in patients undergoing elective cardiac surgery will evaluate the efficacy, safety, and pharmacokinetics of remimazolam, compared with propofol and sevoflurane, during the induction and maintenance of general anesthesia.

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

Remimazolam: Non-Clinical and Clinical Profile of a New Sedative/Anesthetic Agent.
Kilpatrick GJ. · · 2021 · cited 190× · PMID 34354587 · DOI 10.3389/fphar.2021.690875

Verify or expand the search:

Other trials of Remimazolam

Trials testing the same drug.

NCT07251101 — Hemodynamic Effects of Remimazolam vs Propofol During Robot-assisted Gynecologic Surgery · NA · not yet recruiting
NCT07459322 — The Use of Remimazolam Versus Dexmedetomidine for Patients Receiving Drug-Induced Sleep Endoscopy · NA · not yet recruiting
NCT07290205 — Remimazolam NeuroImaging · EARLY_PHASE1 · recruiting
NCT07269808 — Sedation During Endoscopy Using Remimazolam: Efficacy in a Novel Exploration · Phase 3 · recruiting
NCT06231563 — Ketamine for Veterans With Parkinson's Disease · Phase 2 · recruiting

Other recruiting trials for General Anesthesia

Currently open trials in the same condition.

NCT07323420 — Effects of Different Inspiratory:Expiratory Ratios on Respiratory and Recovery Outcomes During Dental Procedures Under G · recruiting
NCT07321041 — Effect of Delivery Time on Umbilical Cord Blood Gas Parameters in Cesarean Sections Under General and Spinal Anesthesia · recruiting
NCT07280546 — Analysis of Breath Sounds During Surgery · recruiting
NCT07203287 — Risk of Acute Complications With Rocuronium vs Cisatracurium in Patients With Chronic Kidney Disease · Phase 4 · recruiting
NCT07074730 — General Anesthesia Versus Spinal Anesthesia With Local Anesthetic Infiltration for Buccal Mucosal Graft in Urethroplasty · NA · recruiting

Other Paion UK Ltd. trials

Trials by the same sponsor.

NCT04670471 — Assessment of the Pharmacodynamic and Pharmacokinetic Interaction of Remimazolam and Remifentanil · Phase 1 · completed
NCT03661489 — Efficacy and Safety of Remimazolam (CNS7056) Compared to Propofol for Intravenous Anesthesia During Elective Surgery · Phase 3 · completed
NCT04113343 — Oral Remimazolam With and Without Alcohol in Healthy Female Subjects · Phase 1 · completed
NCT03329014 — A Trial of Intranasal Remimazolam Pharmacokinetics, Pharmacodynamics, Safety and Bioavailability · Phase 1 · completed
NCT04113564 — Absolute Oral Bioavailability of Remimazolam · Phase 1 · completed

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT01937767 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Paion UK Ltd.
Last refreshed: 15 January 2020

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT01937767.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing