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NCT01904734
A Comparison of Clomiphene Citrate Responses in Men With Hypothalamic Hypogonadism naïve to, and Previously Treated With, Testosterone
Phase 2 trial testing Clomiphene in Hypogonadism, Male in 42 participants. Completed in 31 October 2018.
31 October 2018
Quick facts
| Lead sponsor | Phoenix VA Health Care System |
|---|---|
| Phase | Phase 2 |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | triple |
| Primary purpose | treatment |
| Enrollment | 42 |
| Start date | 1 October 2012 |
| Primary completion | 31 October 2018 |
| Estimated completion | 31 October 2018 |
| Sites | 1 location across United States |
Drugs / interventions tested
- Clomiphene — full drug profile →
Conditions studied
- Hypogonadism, Male — all drugs for Hypogonadism, Male →
Sponsor
Phoenix VA Health Care System — full company profile →
Who can join
Adults 30 to 70, male only, with Hypogonadism, Male. Patients with the condition only — healthy volunteers not accepted.
What's being measured
Primary outcomes are the specific endpoints the trial is designed to prove or disprove.
-
Total serum testosterone
Time frame: at the end of 8 weeks of treatment
laboratory measurement by standard immunometric method
Sponsor's own description
This study aims to explore whether men with low testosterone levels, due to altered brain regulation of male hormone function, who have been previously treated with testosterone, respond as well as men who have not been so treated to clomiphene citrate, an agent commonly used for female infertility that has been shown to improve male hormone secretion in some cases.
Publications & conference data
No peer-reviewed publications indexed yet for this trial. Completed trials usually publish results within 12-18 months.
Verify or expand the search:
- PubMed search for NCT01904734
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other trials of Clomiphene
Trials testing the same drug.
- NCT05866068 — Use of Clomiphene Citrate as an Inhibitor of Ovulation in an Oocyte Cryopreservation Cycle · unknown
- NCT03989024 — Pulsatile Gonadotropin-releasing Hormone for Infertility in Non-obese Patients With Polycystic Ovary Syndrome · Phase 4 · unknown
- NCT03245827 — Hypogonadotropic Hypogonadism in Obese Young Males · Phase 2 · terminated
- NCT04010942 — Vitamin D for Polycystic Ovary Syndrome Clomiphene Resistant Women · Phase 4 · completed
- NCT03400722 — Double Ovarian Stimulation as Accumulation Strategy for Older Infertile Patients With Suboptimal Ovarian Response · Phase 4 · unknown
Other recruiting trials for Hypogonadism, Male
Currently open trials in the same condition.
- NCT06841328 — Fertility Enhancement Through Regenerative Treatment in Ovaries and Testes · recruiting
- NCT06532149 — ERectile Dysfunctions, gOnadotoxicity and Sexual Health Assessment in Men With Lung Cancer · recruiting
- NCT04798469 — Pain Alleviation With Testosterone in Opioid-Induced Hypogonadism · Phase 2 · recruiting
- NCT04049331 — Testosterone Replacement in Male Cancer Survivors With Fatigue and Low Testosterone · Phase 2 · recruiting
- NCT04301765 — Improving Cancer-related Fatigue, Sexual Dysfunction and Quality of Life in Older Men With Cancer and Androgen Deficienc · Phase 2 · recruiting
Other Phoenix VA Health Care System trials
Trials by the same sponsor.
- NCT03330548 — Pilot Study on the Effects of a Plant-Strong Diet on Cardiovascular Risk Factors · NA · completed
- NCT04693728 — Adaptive Strategies for Resilient Intrinsic Self-Regulation in Extremes (RISE) · NA · completed
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT01904734 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Phoenix VA Health Care System
- Last refreshed: 8 March 2021
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT01904734.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing