Last reviewed · How we verify
NCT05866068: CCOI
Use of Clomiphene Citrate as an Inhibitor of Ovulation in an Oocyte Cryopreservation Cycle
trial testing Clomiphene in Infertility, Female in 10 participants. Status unknown.
30 June 2024
Quick facts
| Lead sponsor | Neil Chappell |
|---|---|
| Status | Status unknown |
| Study type | OBSERVATIONAL |
| Enrollment | 10 |
| Start date | 1 July 2023 |
| Primary completion | 30 June 2024 |
| Estimated completion | 31 October 2024 |
| Sites | 1 location across United States |
Drugs / interventions tested
- Clomiphene — full drug profile →
Conditions studied
- Infertility, Female — all drugs for Infertility, Female →
- Infertility — all drugs for Infertility →
Sponsor
Neil Chappell
Who can join
Adults 18 to 42, female only, with Infertility, Female or Infertility. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
In vitro fertilization (IVF) has helped countless couples conceive where they otherwise were unable, but does come at a significant cost. A large portion of that cost is in the medications that allow for controlled ovarian hyperstimulation. One aspect of treatment is in ovulation inhibition to allow for supraphysiologic recruitment of oocytes prior to natural ovulation. Historically, GnRH agonist and antagonists have been used. However, these are subcutaneous injections and can be costly. Clomiphene citrate is a selective estrogen receptor modulator that acts as an estrogen antagonist in the hypothalamus and pituitary and is an inexpensive oral agent. It may be used as an inhibitor of ovulation in IVF in theory but this has never been attempted to the best of our knowledge.
Publications & conference data
No peer-reviewed publications indexed yet for this trial.
Verify or expand the search:
- PubMed search for NCT05866068
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other trials of Clomiphene
Trials testing the same drug.
- NCT03989024 — Pulsatile Gonadotropin-releasing Hormone for Infertility in Non-obese Patients With Polycystic Ovary Syndrome · Phase 4 · unknown
- NCT03245827 — Hypogonadotropic Hypogonadism in Obese Young Males · Phase 2 · terminated
- NCT04010942 — Vitamin D for Polycystic Ovary Syndrome Clomiphene Resistant Women · Phase 4 · completed
- NCT03400722 — Double Ovarian Stimulation as Accumulation Strategy for Older Infertile Patients With Suboptimal Ovarian Response · Phase 4 · unknown
Other recruiting trials for Infertility, Female
Currently open trials in the same condition.
- NCT06771401 — Identification of Biomarkers in Cervical Mucus · NA · recruiting
- NCT06984081 — CAPA In-vitro Oocyte Maturation · NA · recruiting
- NCT07308561 — The Relationship Between Quality of Life, Anxiety Levels, and Attitudes Toward Artificial Intelligence Among Women Under · recruiting
- NCT07175571 — SISTER: Sibling Oocyte Insemination With Frozen Sperm From Third Party Donors: Evaluation of Reproductive Techniques · NA · recruiting
- NCT06193135 — Usefulness of Corifollitropin α as Alternative to Conventional Daily rFSH Protocols in Oocyte Donors Undergoing Pituitar · NA · recruiting
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT05866068 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Neil Chappell
- Last refreshed: 19 May 2023
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05866068.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing