NCT01715844: SANDIA

L-Citrulline Supplementation Pilot Study for Overweight Late Onset Asthmatics

Completed Phase 1 Last updated 2 July 2017

What this trial tests

Phase 1 trial testing L-citrulline in Asthma in 10 participants. Completed in 1 June 2017.

Timeline

7 September 2013

Primary endpoint
1 June 2016

1 June 2017

Quick facts

Lead sponsor	University of Pittsburgh
Phase	Phase 1
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	quadruple
Primary purpose	treatment
Enrollment	10
Start date	7 September 2013
Primary completion	1 June 2016
Estimated completion	1 June 2017
Sites	1 location across United States

Drugs / interventions tested

• L-citrulline (Citrulline) — full drug profile →

Conditions studied

• Asthma — all drugs for Asthma →

Sponsor

University of Pittsburgh

Who can join

Adults 18 to 75, any sex, with Asthma. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

In people who develop asthma after the age of 12 and who are also overweigh, there can be an increased burden of asthma symptoms, more flare-ups, and poorly-controlled asthma when compared to normal weight asthmatics. Certain factors are more abundant in the blood of individuals who are obese. One such factor is derived from the metabolism of an amino acid found in your diet, which is known as L-arginine (Amino acids are most commonly known as the building blocks of proteins, the same as the proteins found in food). This factor is called asymmetric dimethylarginine or ADMA. The balance of L-arginine to ADMA may be important to the health of subjects with asthma. The balance between L-arginine and ADMA plays an important role in producing nitric oxide (NO) in the airways. NO is normally produced in the lung and plays a major role in maintaining airways open and functioning normally. Our research has shown that in subjects with asthma who are overweight and developed asthma later in life, the combination of low L-arginine and high ADMA, may lead to lower NO levels. We are asking participants in this study to take L-citrulline, which is converted to L-arginine by your body, as a supplement for a period of one week. We anticipate that L-citrulline will restore NO levels in the airways, by increasing the ratio of L-arginine to ADMA

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

1. L-Citrulline increases nitric oxide and improves control in obese asthmatics.
   Holguin F, Grasemann H, Sharma S, Winnica D, et al · · 2019 · cited 62× · PMID 31714895 · DOI 10.1172/jci.insight.131733