Who is sponsoring NCT00984308?

NCT00984308 is sponsored by VA Office of Research and Development.

What drugs are being tested in NCT00984308?

Interventions in NCT00984308: CPAP Therapy for Newly Diagnosed Obstructive Sleep Apnea (OSA).

What condition does NCT00984308 study?

NCT00984308 studies Obstructive Sleep Apnea, Stroke, Transient Ischemic Attack, Hypertension.

Is NCT00984308 still recruiting?

NCT00984308 is currently completed. Last updated 14 June 2017.

Are results published for NCT00984308?

Yes — primary outcome results have been posted to ClinicalTrials.gov. See the outcomes section above for details.

Last reviewed 2017-06-14 · How we verify

NCT00984308: Go To Sleep

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Diagnosis and Treatment of Sleep Apnea in Cerebrovascular Disease

Completed Phase 2, PHASE3 Results posted Last updated 14 June 2017

What this trial tests

Phase 2, PHASE3 trial testing CPAP Therapy for Newly Diagnosed Obstructive Sleep Apnea (OSA) in Obstructive Sleep Apnea in 225 participants. Completed in 30 September 2011.

Timeline

23 December 2008

Primary endpoint
30 September 2011

30 September 2011

Quick facts

Lead sponsor	VA Office of Research and Development
Phase	Phase 2, PHASE3
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	none
Primary purpose	treatment
Enrollment	225
Start date	23 December 2008
Primary completion	30 September 2011
Estimated completion	30 September 2011
Sites	2 locations across United States

Drugs / interventions tested

CPAP Therapy for Newly Diagnosed Obstructive Sleep Apnea (OSA)

Conditions studied

Obstructive Sleep Apnea — all drugs for Obstructive Sleep Apnea →
Stroke — all drugs for Stroke →
Transient Ischemic Attack — all drugs for Transient Ischemic Attack →
Hypertension — all drugs for Hypertension →

Sponsor

VA Office of Research and Development — full company profile →

Who can join

40 and older, any sex, with Obstructive Sleep Apnea or Stroke. Patients with the condition only — healthy volunteers not accepted.

Results — posted to ClinicalTrials.gov

Per-arm endpoint measurements with 95% confidence intervals where reported. Source: trial results section.

Sleep Apnea Diagnosis Rate Primary · The entire study period (baseline and up to one-year)

The number of patients with a diagnosis of sleep apnea

Group	Value	95% CI
Intervention	58
Control	5

Hypertension Control Primary · One year

Medication-Adjusted Systolic Blood Pressure

Group	Value	95% CI
Intervention	157.4	± 25
Control	161.6	± 24.3

Sleep Apnea Treatment Rate Secondary · One year

Group	Value	95% CI
Intervention	22
Control	0

Adverse events — posted to ClinicalTrials.gov

Reporting threshold: 0%. Adverse-event reports describe events observed during the trial — not all are caused by the drug.

Intervention

Serious: 5/110 (5%)

Deaths: —

Control

Serious: 2/115 (2%)

Deaths: —

Serious adverse events (5 terms)

Reaction	System	Intervention	Control
Congestive heart failure (CHF)	Cardiac disorders	—	—
stroke	Nervous system disorders	—	—
Transient ischemic attack (TIA)	Nervous system disorders	—	—
DEATH	General disorders	—	—
Acute myocardial infarction (AMI)	Cardiac disorders	—	—

Other adverse events (1 terms — click to expand)

Reaction	System	Intervention	Control
Falls	General disorders	—	—

Most-reported serious reactions: Congestive heart failure (CHF), stroke, Transient ischemic attack (TIA), DEATH, Acute myocardial infarction (AMI).

Data from ClinicalTrials.gov NCT00984308 adverse events section.

Sponsor's own description

Sleep apnea is common among Veterans with cerebrovascular disease (stroke or transient ischemic attack \[TIA\]), leads to hypertension, and is associated with recurrent stroke and death. Although continuous positive airway pressure (CPAP) safely treats sleep apnea, few Veterans with cerebrovascular disease are diagnosed with sleep apnea or offered treatment.

Publications & conference data

3 peer-reviewed publications reference this trial (live from Europe PMC):

Development, Validation, and Assessment of an Ischemic Stroke or Transient Ischemic Attack-Specific Prediction Tool for Obstructive Sleep Apnea.
Sico JJ, Yaggi HK, Ofner S, Concato J, et al · · 2017 · cited 20× · PMID 28416405 · DOI 10.1016/j.jstrokecerebrovasdis.2017.03.042
Diagnosis and Treatment of Sleep Apnea in patients' homes: the rationale and methods of the "GoToSleep" randomized-controlled trial.
Bravata DM, Ferguson J, Miech EJ, Agarwal R, et al · · 2012 · cited 18× · PMID 22334806 · DOI 10.5664/jcsm.1654
Diagnosing and managing sleep apnea in patients with chronic cerebrovascular disease: a randomized trial of a home-based strategy.
Bravata DM, McClain V, Austin C, Ferguson J, et al · · 2017 · cited 17× · PMID 28386781 · DOI 10.1007/s11325-017-1494-5

Verify or expand the search:

Other recruiting trials for Obstructive Sleep Apnea

Currently open trials in the same condition.

NCT07195253 — Oro-myofunctional Characteristics and Obstructive Sleep Apnea in Infants With Down Syndrome · recruiting
NCT07273019 — Tongue Muscular Assessment in Children With Sleep Disordered Breathing · NA · recruiting
NCT07447011 — Glaucoma Respsosne to Lifestyle Corrections in Sleep Apnea · NA · recruiting
NCT07397780 — RPMO2 Oximeter Accuracy During Sleep 1 Trial · active not recruiting
NCT06698809 — Obstructive Sleep Apnea Therapeutic Intervention for REsiDual Sleepiness · NA · recruiting

Other VA Office of Research and Development trials

Trials by the same sponsor.

NCT07456150 — Personalizing Veteran Pain Care: Adapting Coaching Interventions to Support Maintenance of Self-Care · Phase 1 · not yet recruiting
NCT06746727 — The Development of a Transdiagnostic Intervention to Improve Social Functioning and Intimate Relationships Among Veteran · NA · not yet recruiting
NCT07362576 — Perinatal Peer Support for Veterans With Serious Mental Illness · NA · not yet recruiting
NCT06766331 — Integrated Care Versus Usual Care for Opioid Use Disorder and Infectious Diseases in Veterans · NA · not yet recruiting
NCT07397195 — ACT for Veterans With IBD and Mental Health Challenges · NA · not yet recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT00984308 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by VA Office of Research and Development
Last refreshed: 14 June 2017

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT00984308.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing