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NCT00950625
Comparison of Analgesic Efficacy of Intra-peritoneal Lignocaine With Bupivacaine After Laparoscopic Cholecystectomy: A Prospective Randomized Controlled Trial
NA trial testing lignocaine in Laparoscopic Cholecystectomy in 200 participants. Completed in 1 August 2010.
1 August 2010
Quick facts
| Lead sponsor | Aga Khan University |
|---|---|
| Phase | NA |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | double |
| Primary purpose | treatment |
| Enrollment | 200 |
| Start date | 1 August 2009 |
| Primary completion | 1 August 2010 |
| Estimated completion | 1 August 2010 |
| Sites | 1 location across Pakistan |
Drugs / interventions tested
- lignocaine — full drug profile →
- bupevacaine — full drug profile →
Conditions studied
- Laparoscopic Cholecystectomy — all drugs for Laparoscopic Cholecystectomy →
Sponsor
Aga Khan University
Who can join
14 and older, any sex, with Laparoscopic Cholecystectomy. Patients with the condition only — healthy volunteers not accepted.
What's being measured
Primary outcomes are the specific endpoints the trial is designed to prove or disprove.
-
Pain Control after Laparoscopic Cholecystectomy
Time frame: 24 hours after surgery
Sponsor's own description
Although laparoscopic cholecystectomy is associated with less pain than contemporary open procedures; it is definitely not pain free and the magnitude of postoperative shoulder and abdominal pain in the early postoperative period is still quite significant. This postoperative pain is a major concern not only for the patients, but also healthcare workers; and it often contributes to overnight hospital stay after this minimally invasive surgical procedure. Intraperitoneal instillation of local anesthetics at the time of surgery to control pain after laparoscopic cholecystectomy has been extensively studied in numerous randomized trials and found to be extremely useful. Lignocaine and Bupivacaine are two commonly used local anesthetic agents. In view of contradictory results from previous studies, it is not yet clear which of these two agents is superior to the other for pain control in this setting. To answer this question, we have designed a prospective randomized controlled trial and the specific aim of the study is to compare the analgesic efficacy of intraperitoneal lignocaine with intraperitoneal Bupivacaine in the postoperative setting after laparoscopic cholecystectomy. If we can improve pain control after this minimally invasive procedure, it might result in decreased postoperative requirement of narcotic analgesia and its associated side-effects. It may also result in early recovery and the same day discharge of the patients with significant cost-containment for the patient and healthcare systems in future.
Publications & conference data
No peer-reviewed publications indexed yet for this trial. Completed trials usually publish results within 12-18 months.
Verify or expand the search:
- PubMed search for NCT00950625
- Europe PMC full search
- ASCO Meeting Library
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Related trials
Other trials of lignocaine
Trials testing the same drug.
- NCT04166578 — Analgetic Effect of Two Solutions of Intracameral Anesthesia During Cataract Surgery in Patients · completed
- NCT04921046 — Effect of Pretreatment of Lignocaine Versus Midazolam in Prevention of Etomidate Induced Myoclonus. · Phase 4 · completed
Other recruiting trials for Laparoscopic Cholecystectomy
Currently open trials in the same condition.
- NCT07440940 — Timing of Subcostal TAPB Combined With Rectus Sheath Block for Postoperative Pain After Laparoscopic Cholecystectomy · NA · recruiting
- NCT07488078 — Effect of Liberal and Restrictive IV Fluids on Recovery After Gallbladder Surgery · Phase 1 · recruiting
- NCT06632184 — Peritoneal Lavage Using Saline or Saline With Ondansetron for Pain Control After Laparoscopic Cholecystectomy · Phase 4 · active not recruiting
- NCT07445854 — Sensory Analysis and Cutaneous Mapping of Different Regional Anesthesia Techniques · recruiting
- NCT07186803 — AI and Safety in Laparoscopic Cholecystectomy: A Randomized Controlled Trial · Phase 3 · recruiting
Other Aga Khan University trials
Trials by the same sponsor.
- NCT07475793 — Image Guided Genicular Nerve Radiofrequency Ablation for Chronic Knee Osteoarthritis · NA · not yet recruiting
- NCT07197684 — Ultrasound Guided Pecs Block and Ketamine Infusion for Preventing Chronic Pain in Patients Undergoing Breast Cancer Surg · NA · not yet recruiting
- NCT07356063 — Self-Efficacy Enhancement Using a Multicomponent Support Group for Caregivers of Children With DMD/SMA · NA · not yet recruiting
- NCT07451951 — Effectiveness of SQLNS vs MQLNS for Prevention of Undernutrition in Children 6-12 Months · NA · not yet recruiting
- NCT07357350 — Effectiveness of Pain Management Interventions in Patients With Abdominal and Pelvic Cancer · not yet recruiting
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT00950625 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Aga Khan University
- Last refreshed: 24 January 2011
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT00950625.
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