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NCT00869037
Analgesia After Total Knee Arthroplasty: Randomized Controlled Trial Comparing (a) Periarticular Multimodal Technique With (B) Continuous Femoral Nerve Block + Posterior Capsular Injection
Phase 4 trial testing Periarticular Injection in Analgesia in 90 participants. Status unknown.
1 July 2011
Quick facts
| Lead sponsor | University of Manitoba |
|---|---|
| Phase | Phase 4 |
| Status | Status unknown |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | quadruple |
| Primary purpose | treatment |
| Enrollment | 90 |
| Start date | 1 March 2009 |
| Primary completion | 1 July 2011 |
| Estimated completion | 1 February 2012 |
| Sites | 1 location across Canada |
Drugs / interventions tested
- Periarticular Injection — full drug profile →
- CFNB + Posterior Capsular Injection — full drug profile →
Conditions studied
- Analgesia — all drugs for Analgesia →
Sponsor
University of Manitoba
Who can join
Adults 18 to 70, any sex, with Analgesia. Patients with the condition only — healthy volunteers not accepted.
What's being measured
Primary outcomes are the specific endpoints the trial is designed to prove or disprove.
-
Static and dynamic pain scores until post-operative day 2 (POD 2)
Time frame: 9:00 and 15:30 daily for the first 2 postoperative days
Sponsor's own description
The recovery from knee replacement surgery often involves a significant amount of pain. The best way to prevent/treat this pain is unknown. This study will compare two accepted methods of pain control in order to determine which is superior. The first method involves the injection of a solution containing multiple medications into the knee joint at the time of surgery. The second method involves the placement of a catheter adjacent to the femoral nerve which senses pain from the knee. This catheter is used to deliver local anesthetic which serves to block the transmission of pain signals from the nerve. The catheter will be left in place until 2 days after surgery. This method is combined with injection of local anesthetic in a particular area of the knee joint at the time of surgery. Patients will be followed until 2 days after surgery in order to determine which method is superior. We believe the second method will be deemed superior.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
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Prospective randomized trial of continuous femoral nerve block with posterior capsular injection versus periarticular injection for analgesia in primary total knee arthroplasty.
Aragola S, Arenson B, Tenenbein M, Bohm E, et al · · 2021 · cited 1× · PMID 33908425 · DOI 10.1503/cjs.020519
Verify or expand the search:
- PubMed search for NCT00869037
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other trials of Periarticular Injection
Trials testing the same drug.
- NCT06800846 — Comparative Analgesic Effect After Total Knee Arthroplasty Between Intraosseous and Peri-articular Injection · Phase 4 · enrolling by invitation
- NCT04648072 — How Does the Addition of Adductor Canal Block to Local Infiltration Affect Recovery in Patients Undergoing Total Knee Ar · NA · completed
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Other University of Manitoba trials
Trials by the same sponsor.
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT00869037 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by University of Manitoba
- Last refreshed: 23 March 2011
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT00869037.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing