NCT00496119

Proton Beam Therapy for Chordoma Patients

Active, enrolled Phase 2 Last updated 16 December 2025

What this trial tests

Phase 2 trial testing Proton Beam Therapy in Chordoma in 19 participants. Participants enrolled and being followed up; not accepting new ones.

Timeline

18 September 2006

Primary endpoint
31 December 2027

31 December 2027

Quick facts

Lead sponsor	M.D. Anderson Cancer Center
Phase	Phase 2
Status	Active, enrolled
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	none
Primary purpose	treatment
Enrollment	19
Start date	18 September 2006
Primary completion	31 December 2027
Estimated completion	31 December 2027
Sites	1 location across United States

Drugs / interventions tested

• Proton Beam Therapy
• Photon Beam Therapy

Conditions studied

• Chordoma — all drugs for Chordoma →

Sponsor

M.D. Anderson Cancer Center — full company profile →

Who can join

Eligibility, any sex, with Chordoma. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

The goal of this clinical research study is to learn if proton beam therapy, with or without photon beam radiation therapy, is effective in the treatment of skull base chordoma. The safety of this treatment will also be studied.

Publications & conference data

3 peer-reviewed publications reference this trial (live from Europe PMC):

1. Proton beam therapy for cancer in the era of precision medicine.
   Hu M, Jiang L, Cui X, Zhang J, et al · · 2018 · cited 57× · PMID 30541578 · DOI 10.1186/s13045-018-0683-4
2. Radiotherapy for Mobile Spine and Sacral Chordoma: A Critical Review and Practical Guide from the Spine Tumor Academy.
   Redmond KJ, Schaub SK, Lo SL, Khan M, et al · · 2023 · cited 17× · PMID 37190287 · DOI 10.3390/cancers15082359
3. Advances in Radiation Therapy for Primary Bone Malignancies.
   Li L, Tao W, Eid JE, Gupta S, et al · · 2026 · PMID 41823226 · DOI 10.1177/15330338261425345