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NCT06804447: SUPERMAN
Pencil Beam Scanning Proton Beam Radiotherapy for the Management of Abdominal Neuroblastoma
NA trial testing Proton Beam Therapy in Abdominal Neuroblastoma in 100 participants. Not yet recruiting.
1 March 2030
Quick facts
| Lead sponsor | The Christie NHS Foundation Trust |
|---|---|
| Phase | NA |
| Status | Not yet recruiting |
| Study type | INTERVENTIONAL |
| Allocation | na |
| Design | single group |
| Masking | none |
| Primary purpose | treatment |
| Enrollment | 100 |
| Start date | 1 March 2025 |
| Primary completion | 1 March 2030 |
| Estimated completion | 1 March 2030 |
Drugs / interventions tested
- Proton Beam Therapy
Conditions studied
- Abdominal Neuroblastoma — all drugs for Abdominal Neuroblastoma →
Sponsor
The Christie NHS Foundation Trust
Who can join
3 Months and older, any sex, with Abdominal Neuroblastoma. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Proton Beam Therapy (PBT) and Evaluative Commissioning in Protons (ECIP): PBT is an advanced radiotherapy technique. There are two National Health Service (NHS) PBT treatment centres in the United Kingdom, in Manchester and London. The NHS is committed to ensuring the best use of this limited resource by investigating which patients will benefit from PBT. ECIP is a programme of studies exploring the role of PBT in different types of cancer funded by NHS England. ECIP studies are not randomised, eligible patients will be offered PBT. Any eligible UK patient can be referred, and accommodation is available for patients who don't live close to a PBT centre. The main benefit of PBT, compared with standard photon radiotherapy, is predicted reduction in radiation dose to surrounding healthy tissues. With photon radiotherapy, some radiation passes beyond the target area, affecting healthy tissues and causing side-effects. With PBT, the radiation dose stops within the target area, causing less damage to surrounding tissues, and limiting side effects. SUPERMAN: SUPERMAN is a study within the ECIP programme. It is sometimes not entirely clear whether PBT or photon radiotherapy is better for the treatment of a patient with abdominal neuroblastoma. The aim of SUPERMAN is to choose the best radiotherapy technique and to better understand how to monitor and adapt PBT for these patients.
Publications & conference data
No peer-reviewed publications indexed yet for this trial.
Verify or expand the search:
- PubMed search for NCT06804447
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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- NCT06421649 — Investigating the Role of Adjuvant Proton Beam Therapy in Patients With Parotid Carcinoma · NA · not yet recruiting
- NCT03234842 — Dose Escalated Proton Beam Therapy or Photon Therapy for Esophageal Cancer · Phase 2 · withdrawn
- NCT02395523 — Hypofractionated Proton Beam Radiotherapy for Inoperable Hepatocellular Carcinoma · NA · completed
Other The Christie NHS Foundation Trust trials
Trials by the same sponsor.
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT06804447 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by The Christie NHS Foundation Trust
- Last refreshed: 3 February 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT06804447.
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