NCT00476593 is a NA clinical trial of Diclofenac in Uveitis, sponsored by Norwegian University of Science and Technology.

Who is sponsoring NCT00476593?

NCT00476593 is sponsored by Norwegian University of Science and Technology.

What drugs are being tested in NCT00476593?

Interventions in NCT00476593: Diclofenac, Dexamethasone.

What condition does NCT00476593 study?

NCT00476593 studies Uveitis, Iritis, Iridocyclitis, Anterior Uveitis, Macular Edema.

Is NCT00476593 still recruiting?

NCT00476593 is currently completed. Last updated 28 March 2017.

Are results published for NCT00476593?

Yes — primary outcome results have been posted to ClinicalTrials.gov. See the outcomes section above for details.

Last reviewed 2017-03-28 · How we verify

NCT00476593

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Retinal Optical Coherence Tomography and Multifocal Electroretinogram; Establishing Normal Ranges Related to Age and Reproductive Factors; With the Use of Anti-inflammatory Medications;In Uncomplicated Anterior Uveitis; Anatomy and Function.

Completed NA Results posted Last updated 28 March 2017

What this trial tests

NA trial testing Diclofenac in Uveitis in 218 participants. Completed in 1 December 2010.

Timeline

1 September 2005

Primary endpoint
1 December 2009

1 December 2010

Quick facts

Lead sponsor	Norwegian University of Science and Technology
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	none
Primary purpose	basic science
Enrollment	218
Start date	1 September 2005
Primary completion	1 December 2009
Estimated completion	1 December 2010
Sites	2 locations across Norway

Drugs / interventions tested

Diclofenac (DICLOFENAC) — full drug profile →
Dexamethasone (dexamethasone) — full drug profile →

Conditions studied

Uveitis — all drugs for Uveitis →
Iritis — all drugs for Iritis →
Iridocyclitis — all drugs for Iridocyclitis →
Anterior Uveitis — all drugs for Anterior Uveitis →

Sponsor

Norwegian University of Science and Technology

Who can join

18 and older, any sex, with Uveitis or Iritis. Healthy volunteers can join.

What's being measured

Primary outcomes are the specific endpoints the trial is designed to prove or disprove.

Macular Thickness Measured With the OCT; in Relation to Age, Sex, Reproductive Factors and the Use of Anti-inflammatory Eye Drops in Health; in Uncomplicated Anterior Uveitis.
Time frame: Macular thickness measured with the OCT
Macular thickness was assessed with the OCT in healthy subjects and in patients with anterior uveitis. Data was analyzed with respect to age, sex, parity, the use of hormonal therapy, after treatment with to types of anti-inflammatory eye drops, and in uncomplicated uveitis.

Sponsor's own description

Retinal optical coherence tomography (OCT) is an established technology which enables a detailed cross-sectional visualization of the retinal micro-anatomy, and an objective measurement of its thickness in-vivo. Multifocal electroretinogram (MfERG) measures function of the central retina. Both technologies are relatively new and they provide complimentary to each other information on retinal anatomy and function. The aims of this study is to establish normal ranges for OCT and mfERG measurements related to age, gender and reproductive factors such as parity and the use of contraception in Norwegians; to assess the presumably healthy central retina with the use of anti-inflammatory medication with relation to age and sex ; to study the frequency and extent of retinal thickening and change in retinal function in patients with anterior uveitis not complicated with macular edema; to assess whether the presence of the HLA-B27 haplotype or uveitis recidive affects macular thickening/function in uveitis.

Publications & conference data

No peer-reviewed publications indexed yet for this trial. Completed trials usually publish results within 12-18 months.

Verify or expand the search:

Other trials of Diclofenac

Trials testing the same drug.

NCT03595150 — Diclofenac for Prevention of Post-ERC Pancreatitis · Phase 2, PHASE3 · not yet recruiting
NCT07071012 — Pain Control After Open Radical Nephrectomy: Thoracic Paravertebral Block Versus External Oblique Intercostal Block · NA · completed
NCT07203651 — Comparison Between Diclofenac and Sterile Water Injection for Relief of Labour Associated Bachache · NA · active not recruiting
NCT06918340 — Evaluation of Analgesic Efficacy of Lidocaine and Diclofenac Spray in Radial Artery Blood Gas Sampling by Visual Analogu · Phase 4 · active not recruiting
NCT06566794 — KF2022#4-trial: Effects of a Beta Blocker and NSAID on CYP Mediated Drug Metabolism · NA · completed

Other recruiting trials for Uveitis

Currently open trials in the same condition.

NCT07262437 — Targeting Immunosuppressive Treatment for Non-infectious Uveitis Using Aqueous Humor Cytokine Profiles · NA · active not recruiting
NCT07176130 — Demographics and Clinical Characteristics of Ocular Inflammatory Diseases in Singapore · active not recruiting
NCT06974162 — Metagenomics for Ocular Inflammation · recruiting
NCT06431373 — A Study of Brepocitinib in Adults With Active, Non-Infectious, Non-Anterior Uveitis · Phase 3 · active not recruiting
NCT06310837 — Effect of Immunosuppressants With Adalimumab Biosimilars vs Corticosteroids on Noninfectious Uveitis · NA · active not recruiting

Other Norwegian University of Science and Technology trials

Trials by the same sponsor.

NCT07521891 — Socket-leg Interface Movements in Transtibial Amputees · NA · not yet recruiting
NCT07463001 — Optimization and Testing Effectiveness of a Collaborative Intervention for School Attendance Problems in Norwegian Munic · NA · not yet recruiting
NCT07422597 — Prostate Risk Or Radiology Assessment Non-inferiority Design, Upfront MRI or Risk Calculator in Men With Suspected Prost · NA · recruiting
NCT06558851 — The Effect of Systematic Endurance Training in Treatment of Women With Lipedema · NA · active not recruiting
NCT06893874 — A Pragmatic Trial of Machine Prescription for Migraine · recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT00476593 (US National Library of Medicine, public domain)
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Norwegian University of Science and Technology
Last refreshed: 28 March 2017

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT00476593.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing