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NCT06558851: LipidEx
The Effect of Systematic Endurance Training in Treatment of Women With Lipedema
NA trial testing High intensity endurance training in Lipedema in 62 participants. Participants enrolled and being followed up; not accepting new ones.
31 July 2026
Quick facts
| Lead sponsor | Norwegian University of Science and Technology |
|---|---|
| Phase | NA |
| Status | Active, enrolled |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | crossover |
| Masking | none |
| Primary purpose | treatment |
| Enrollment | 62 |
| Start date | 1 September 2025 |
| Primary completion | 31 July 2026 |
| Estimated completion | 31 July 2026 |
| Sites | 1 location across Norway |
Drugs / interventions tested
- High intensity endurance training
Conditions studied
- Lipedema — all drugs for Lipedema →
Sponsor
Norwegian University of Science and Technology
Who can join
Adults 18 to 65, female only, with Lipedema. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Lipedema is a chronic adipose tissue disorder that primarily affects women. The etiology remains unclear and involves abnormal buildup of fat mainly in the lower limbs. It causes physical and psychological morbidity, often with significant impact of daily life. Effective treatment options are still limited, primary involving conservative measures such as compression therapy. Regular endurance training is known to have positive effects on pain management in other disorders, as well as beneficial effects on obesity management. Thus, LipidEx aims to explore the potential of high-intensity interval training (HIIT) as a novel therapeutic option for women with lipedema. We will now perform a cross-over randomized controlled trial (RCT) exploring the effects of 12 weeks of HIIT compared to a control period of usual care. Primary outcomes include changes in pain, and secondary outcomes include changes in adipose tissue mass and quality of life. Exploratory outcomes include changes in inflammatory markers, metabolites, and lipoprotein subfractions in blood and adipose tissue.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
Stage 1 Registered Report: Effects of high-intensity interval training in women with lipedema - protocol for a randomized controlled trial with sequential intervention and control periods (The LipidEx study)
Sæther JC, Presthus RM, Undebakke R, Madsen L, et al · · 2026 · DOI 10.12688/f1000research.180100.1
Verify or expand the search:
- PubMed search for NCT06558851
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other recruiting trials for Lipedema
Currently open trials in the same condition.
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- NCT07468097 — The Impact of Metabolic Status on Pain and Central Sensitization in Women With Lipedema: A Cross-Sectional Observational · recruiting
- NCT07294014 — Investigation of Medial Longitudinal Arch and Foot Function in Patients With Lipedema · recruiting
- NCT07458932 — Evaluation of Physical Activity in Women With Lipedema · recruiting
- NCT06770634 — Investigation of Central Sensitization and Associated Factors in Patients With Lipedema · recruiting
Other Norwegian University of Science and Technology trials
Trials by the same sponsor.
- NCT07521891 — Socket-leg Interface Movements in Transtibial Amputees · NA · not yet recruiting
- NCT07463001 — Optimization and Testing Effectiveness of a Collaborative Intervention for School Attendance Problems in Norwegian Munic · NA · not yet recruiting
- NCT07422597 — Prostate Risk Or Radiology Assessment Non-inferiority Design, Upfront MRI or Risk Calculator in Men With Suspected Prost · NA · recruiting
- NCT06893874 — A Pragmatic Trial of Machine Prescription for Migraine · recruiting
- NCT06571175 — Quantification of Myocardial Fibrosis in Aortis Stenosis · enrolling by invitation
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT06558851 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Norwegian University of Science and Technology
- Last refreshed: 5 December 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT06558851.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing