NCT00004705 is a NA clinical trial of amiloride in Cystic Fibrosis, sponsored by FDA Office of Orphan Products Development.

Who is sponsoring NCT00004705?

NCT00004705 is sponsored by FDA Office of Orphan Products Development.

What drugs are being tested in NCT00004705?

Interventions in NCT00004705: amiloride, uridine.

What condition does NCT00004705 study?

NCT00004705 studies Cystic Fibrosis.

Is NCT00004705 still recruiting?

NCT00004705 is currently completed. Last updated 24 March 2015.

Last reviewed 2015-03-24 · How we verify

NCT00004705

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Study of Uridine Triphosphate (UTP) as an Aerosol Spray for Cystic Fibrosis

Completed NA Last updated 24 March 2015

What this trial tests

NA trial testing amiloride in Cystic Fibrosis. Completed in 1 January 1999.

Timeline

1 September 1996

1 January 1999

Quick facts

Lead sponsor	FDA Office of Orphan Products Development
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Primary purpose	treatment
Start date	1 September 1996
Estimated completion	1 January 1999

Drugs / interventions tested

amiloride (AMILORIDE) — full drug profile →
uridine — full drug profile →

Conditions studied

Cystic Fibrosis — all drugs for Cystic Fibrosis →

Sponsor

FDA Office of Orphan Products Development — full company profile →

Who can join

4 and older, any sex, with Cystic Fibrosis. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

OBJECTIVES: I. Determine the stability of uridine triphosphate (UTP) and examine the metabolism of exogenous nucleotides on airway epithelial surfaces in patients with cystic fibrosis. II. Determine the acute safety and efficacy of aerosolized UTP in children with cystic fibrosis.

Publications & conference data

No peer-reviewed publications indexed yet for this trial. Completed trials usually publish results within 12-18 months.

Verify or expand the search:

Other trials of amiloride

Trials testing the same drug.

NCT06923709 — Beneficial Effect of Amiloride on Progression of Chronic Kidney Disease · Phase 2 · recruiting

Other recruiting trials for Cystic Fibrosis

Currently open trials in the same condition.

NCT07437105 — Dose Escalation Study Evaluating the Safety and Pharmacokinetics of VX-272 in Healthy Participants · Phase 1 · recruiting
NCT07283770 — Dose Escalation Study Evaluating the Safety and Pharmacokinetics of VX-581 in Healthy Participants · Phase 1 · recruiting
NCT07274631 — A Cohort for Inflammatory Respiratory Diseases: From Phenotyping to Personalised Medicine · recruiting
NCT06810167 — Assessing Tenapanor as a Treatment of CF-related Constipation. · Phase 3 · recruiting
NCT06962852 — A Long-term Study to Monitor the Health Status of People With Cystic Fibrosis Who Took Part in a Previous Study With BI · Phase 1, PHASE2 · active not recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT00004705 (US National Library of Medicine, public domain)
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by FDA Office of Orphan Products Development
Last refreshed: 24 March 2015

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT00004705.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing