NCT00001625

Methods for Measuring Insulin Sensitivity

Completed Last updated 2 July 2017

What this trial tests

trial in Obesity in 480 participants. Completed in 11 April 2007.

Timeline

3 April 1997

11 April 2007

Quick facts

Lead sponsor	National Center for Complementary and Integrative Health (NCCIH)
Status	Completed
Study type	OBSERVATIONAL
Enrollment	480
Start date	3 April 1997
Estimated completion	11 April 2007
Sites	1 location across United States

Conditions studied

• Obesity — all drugs for Obesity →
• Hypertension — all drugs for Hypertension →
• Diabetes-Mellitus, Non-Insulin Dependent — all drugs for Diabetes-Mellitus, Non-Insulin Dependent →

Sponsor

National Center for Complementary and Integrative Health (NCCIH) — full company profile →

Who can join

Adults 21 to 65, any sex, with Obesity or Hypertension. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Patients with high blood pressure, diabetes, and who are overweight are known to have defects in the way their body responds to insulin. The purpose of this study is to develop better methods for measuring the way body tissue responds to insulin and sugar (glucose).

Researchers are planning to study four groups of patients.

1. Normal volunteers
2. Patients who have mild to moderate high blood pressure
3. Patients who are overweight
4. Patients who have mild to moderate diabetes controlled with oral medication

In this study patients and volunteers will undergo two separate tests designed to determine how well insulin is working in the body. The first test is called a glucose clamp test. Patients will have two needles placed in the veins of their arms. One needle will be used to take blood samples, the other needle will be used to inject doses of sugar (glucose) and insulin.

The second test is called the frequently sample intravenous glucose tolerance test. In this test patients will have sugar (glucose) injected into their veins followed by a slow injected dose (infusion) of insulin. Researchers will periodically take blood samples during the test.

Patients participating in the study will not directly benefit from it. However, the information gained from this study may be useful for improving the diagnosis and therapy of diseases such as diabetes, obesity, and high blood pressure (hypertension).

Publications & conference data

No peer-reviewed publications indexed yet for this trial. Completed trials usually publish results within 12-18 months.