TRPV1 — Drug Target

All drugs that target TRPV1 — marketed and clinical-stage. Includes 3 drug classes acting on this target.

Drug classes

TRPV1 antagonist · Topical analgesic · TRPV1 receptor modulator

Phase 3 pipeline (2)

• KPS-0373, High dose · Kissei Pharmaceutical Co., Ltd. · TRPV1 antagonist · Pain Management
  KPS-0373 is a selective TRPV1 antagonist that blocks pain signaling through the transient receptor potential vanilloid 1 channel.
• NGX-4010, 8% capsaicin patch · NeurogesX · Topical analgesic · Pain management
  NGX-4010, an 8% capsaicin patch, works by activating TRPV1 receptors to reduce pain.

Phase 2 pipeline (5)

• AGN-210669 · Allergan · TRPV1 antagonist · Pain Management
  AGN-210669 is a selective inhibitor of the transient receptor potential vanilloid 1 (TRPV1) channel that reduces pain signaling in sensory neurons.
• Capsaicin, USP 0.0375% · Express Specialty Pharmacy · Topical analgesic · Pain Management
  Activates TRPV1 receptors
• Capsaicin 1% oral solution · Georg Kägi, MD · Topical analgesic · Pain management
  Capsaicin activates TRPV1 receptors, leading to the release of substance P and subsequent pain relief.
• CRx-197 · Zalicus · TRPV1 receptor modulator · Pain
  CRx-197 is a small molecule that modulates the TRPV1 receptor.
• Capsaicin 0.1% Cream · Henry Ford Health System · Topical analgesic · Dermatology
  Activates TRPV1 receptors to reduce pain