TNF-alpha — Drug Target
All drugs that target TNF-alpha — marketed and clinical-stage. Includes 11 drug classes acting on this target.
Drug classes
TNF inhibitor (tapered dosing strategy) · TNF inhibitor (class-level; specific agent varies) · Monoclonal Antibody · TNF-alpha inhibitor · Immunomodulator · TNF inhibitor · TNF-alpha inhibitor monoclonal antibody (biosimilar) · Anti-inflammatory, Immunomodulator · TNF-alpha inhibitor (monoclonal antibody biosimilar) · TNF-alpha inhibitor (monoclonal antibody) · Anti-TNF agents
Marketed (4)
- Tapered doses of TNFi · University Health Network, Toronto · TNF inhibitor (tapered dosing strategy) · Immunology
Tapered doses of TNF inhibitors gradually reduce the dose of anti-TNF therapy to assess disease control and minimize long-term immunosuppression. - Switch to a second anti-TNF drug alone · Védrines, Philippe, M.D. · TNF inhibitor (class-level; specific agent varies) · Immunology / Rheumatology
Switching to a second anti-TNF agent involves discontinuing one TNF inhibitor and initiating a different TNF inhibitor to maintain or restore therapeutic response in inflammatory conditions. - TNF Inhibitor · Pfizer · Monoclonal Antibody · Immunology
- Certolizumab Pegol (CZP) · UCB Pharma · TNF-alpha inhibitor · Immunology
Certolizumab pegol is a TNF-alpha inhibitor that binds to and neutralizes tumor necrosis factor-alpha, reducing inflammatory signaling.
Phase 3 pipeline (18)
- SC golimumab · Merck Sharp & Dohme LLC · TNF-alpha inhibitor · Immunology
SC golimumab is a monoclonal antibody that binds to tumor necrosis factor-alpha (TNF-alpha), preventing its interaction with cell surface TNF receptors and subsequent inflammatory response. - infliximab infusion; AZA placebo caps · Centocor Ortho Biotech Services, L.L.C. · TNF-alpha inhibitor · Immunology
Infliximab is a chimeric monoclonal antibody that binds to tumor necrosis factor-alpha (TNF-alpha), preventing its interaction with cell surface TNF receptors and thereby inhibiting the inflammatory response. - EU Simponi · Bio-Thera Solutions · TNF-alpha inhibitor · Immunology
Simponi is a TNF-alpha inhibitor that blocks tumor necrosis factor signaling to reduce inflammation in autoimmune diseases. - SB27 · Samsung Bioepis Co., Ltd. · TNF-alpha inhibitor · Rheumatology
SB27 is a biosimilar to adalimumab, a TNF-alpha inhibitor. - CDP870 · Otsuka Pharmaceutical Co., Ltd. · TNF-alpha inhibitor · Immunology
CDP870 is a pegylated TNF-alpha inhibitor that binds and neutralizes tumor necrosis factor-alpha to reduce inflammatory responses. - Open-labelAdalimumabRescue · Abbott · TNF-alpha inhibitor · Immunology
Adalimumab is a TNF-alpha inhibitor that blocks tumor necrosis factor-alpha to reduce inflammation and immune-mediated disease activity. - Thalidomide (100mg) · Cancer Institute and Hospital, Chinese Academy of Medical Sciences · Immunomodulator · Oncology
Thalidomide acts as an immunomodulatory agent, inhibiting the release of tumor necrosis factor-alpha (TNF-alpha) and other pro-inflammatory cytokines. - Biologic TNFi · Pfizer · TNF inhibitor · Immunology
A TNF inhibitor biologic that blocks tumor necrosis factor (TNF) to reduce inflammatory immune responses. - US-licensed Humira · Celltrion · TNF-alpha inhibitor · Immunology
Humira is a monoclonal antibody that targets and binds to tumor necrosis factor-alpha (TNF-alpha), preventing it from interacting with its cell surface receptor and thereby reducing inflammation. - CT-P17 SC · Celltrion · TNF-alpha inhibitor monoclonal antibody (biosimilar) · Immunology / Rheumatology
CT-P17 SC is a subcutaneous formulation of a monoclonal antibody targeting TNF-alpha to reduce inflammatory cytokine signaling. - Thalidomide, Dexamethasone · Grupo de Estudos Multicentricos em Onco-Hematologia · Anti-inflammatory, Immunomodulator · Oncology
Thalidomide inhibits the release of tumor necrosis factor-alpha (TNF-alpha), a cytokine involved in inflammation and immune response. - Simponi (Golimumab) · Alvotech Swiss AG · TNF-alpha inhibitor · Immunology
Simponi (Golimumab) is a monoclonal antibody that selectively binds to and inhibits tumor necrosis factor-alpha (TNF-alpha), a pro-inflammatory cytokine. - CT-P13 SC Auto-injector · Celltrion · TNF-alpha inhibitor (monoclonal antibody biosimilar) · Immunology
CT-P13 SC is a subcutaneous auto-injector formulation of infliximab, a TNF-alpha inhibitor that blocks tumor necrosis factor signaling to reduce inflammation. - Certolizumab pegol (CDP870) · UCB Pharma · TNF-alpha inhibitor · Immunology
Certolizumab pegol is a TNF-alpha inhibitor that binds to and neutralizes tumor necrosis factor-alpha, reducing inflammatory signaling. - placebo adalimumab, placebo MTX · Abbott · TNF-alpha inhibitor · Immunology
Adalimumab is a monoclonal antibody that binds to tumor necrosis factor-alpha (TNF-alpha), preventing its interaction with cell surface TNF receptors and thereby reducing inflammation. - etanercept Treatment · Assistance Publique Hopitaux De Marseille · TNF-alpha inhibitor · Immunology
Etanercept is a tumor necrosis factor-alpha (TNF-alpha) inhibitor that works by binding to TNF-alpha and preventing it from interacting with its receptors on cell surfaces. - Double-Blind Adalimumab/Placebo + MTX · Abbott · TNF-alpha inhibitor (monoclonal antibody) · Immunology
Adalimumab is a TNF-alpha inhibitor that blocks tumor necrosis factor-alpha signaling to reduce inflammation, combined with methotrexate for enhanced immunosuppressive effect. - adalimumab (D2E7) · Abbott · TNF inhibitor · Immunology
Adalimumab is a fully human monoclonal antibody that selectively binds to tumor necrosis factor-alpha (TNF-alpha), preventing its interaction with cell surface TNF receptors.
Phase 2 pipeline (11)
- Anti TNF Alfa. · Carmel Medical Center · TNF-alpha inhibitor · Immunology
Anti TNF Alfa works by binding to and inhibiting tumor necrosis factor-alpha, a cytokine involved in systemic inflammation. - Anti TNF therapy including infliximab · Janssen Biotech, Inc. · TNF-alpha inhibitor · Immunology
Blocks tumor necrosis factor-alpha (TNF-alpha) by binding to it and preventing it from interacting with cell surface TNF receptors. - Infliximab; Gemcitabine · Centocor, Inc. · TNF-alpha inhibitor · Immunology
Infliximab is a chimeric monoclonal antibody that binds to tumor necrosis factor-alpha (TNF-alpha), preventing its interaction with cell surface TNF receptors. - AMG102 · UNICANCER · TNF-alpha inhibitor · Oncology
AMG102 is a recombinant human tumor necrosis factor (TNF) receptor fusion protein. - Anti-TNF Drug · Schneider Children's Medical Center, Israel · TNF-alpha inhibitor · Immunology
Anti-TNF drugs block the action of tumor necrosis factor-alpha (TNF-alpha), a protein involved in systemic inflammation. - Adalimumab, new formulation · AbbVie (prior sponsor, Abbott) · TNF-alpha inhibitor · Immunology
Adalimumab is a monoclonal antibody that binds to and inhibits tumor necrosis factor-alpha (TNF-alpha), a pro-inflammatory cytokine. - L19TNF and TMZ · Philogen S.p.A. · TNF-alpha inhibitor · Oncology
TNF-alpha inhibitor - Adalimumab, current formulation · AbbVie (prior sponsor, Abbott) · TNF-alpha inhibitor · Immunology
Tumor necrosis factor-alpha inhibitor - Anti-TNF agents · Altuğ Güner · TNF-alpha inhibitor · Immunology
Anti-TNF agents work by binding to and inhibiting tumor necrosis factor-alpha (TNF-alpha), a pro-inflammatory cytokine involved in systemic inflammation. - Adalimumab PFS and Pen · Samsung Bioepis Co., Ltd. · TNF-alpha inhibitor · Immunology
TNF-alpha inhibitor - Anti-tumor necrosis factor alpha agents · El-Hussuna, Alaa, M.D. · Anti-TNF agents · Immunology
Anti-tumor necrosis factor alpha agents work by blocking the action of tumor necrosis factor-alpha (TNF-alpha), a protein involved in systemic inflammation.
Phase 1 pipeline (4)
- Adverse Reactions of Enbrel subcutaneously · ASIS Corporation · TNF-alpha inhibitor · Immunology
Tumor necrosis factor-alpha inhibitor - Adalimumab-US · Pfizer · TNF-alpha inhibitor · Immunology
Tumor necrosis factor-alpha inhibitor - Adalimumab European source · Synermore Biologics Co., Ltd. · TNF-alpha inhibitor · Immunology
Tumour necrosis factor-alpha inhibitor - Adalimumab SC · Centre for Human Drug Research, Netherlands · TNF-alpha inhibitor · Immunology
Tumour necrosis factor-alpha inhibitor