PDE4 — Drug Target

All drugs that target PDE4 — marketed and clinical-stage. Includes 3 drug classes acting on this target.

Drug classes

Phosphodiesterase 4 Inhibitor [EPC] · Phosphodiesterase 4 (PDE4) inhibitor · PDE4 inhibitor

Marketed (4)

• Otezla · Amgen · Phosphodiesterase 4 Inhibitor [EPC] · Immunology
  Apremilast inhibits PDE4, increasing intracellular cAMP levels, but the exact therapeutic mechanism is unclear.
• Apremilast (CC-10004) · Virginia Clinical Research, Inc. · Phosphodiesterase 4 (PDE4) inhibitor · Immunology
  Apremilast inhibits phosphodiesterase 4 (PDE4) to reduce inflammatory cytokine production and modulate immune cell function.
• Crisaborole ointment, 2% · Pfizer · Phosphodiesterase 4 (PDE4) inhibitor · Dermatology
  Crisaborole inhibits phosphodiesterase 4 (PDE4), reducing inflammatory mediator production in immune cells.
• Crisaborole Vehicle · Pfizer · Phosphodiesterase 4 (PDE4) inhibitor · Dermatology
  Crisaborole is a phosphodiesterase 4 (PDE4) inhibitor that reduces inflammatory cytokine production in atopic dermatitis.

Phase 3 pipeline (35)

• crisaborole ointment · Pfizer · PDE4 inhibitor · Dermatology
  Crisaborole inhibits phosphodiesterase 4 (PDE4), leading to increased levels of cyclic AMP (cAMP) which has anti-inflammatory effects.
• GSK576428 · GlaxoSmithKline · PDE4 inhibitor · Immunology
  GSK576428 is a selective inhibitor of phosphodiesterase 4 (PDE4) that reduces inflammatory mediator production by increasing intracellular cAMP levels in immune cells.
• PF-06947386 · Pfizer · PDE4 inhibitor · Immunology
  PF-06947386 is a selective inhibitor of phosphodiesterase 4 (PDE4) that reduces inflammatory signaling by increasing intracellular cAMP levels.
• LEO 90100 · LEO Pharma · Phosphodiesterase 4 (PDE4) inhibitor · Dermatology
  LEO 90100 is a topical phosphodiesterase 4 (PD4) inhibitor that reduces inflammatory cytokine production in skin.
• LAS41008 · Almirall, S.A. · PDE4 inhibitor · Immunology
  LAS41008 is a selective phosphodiesterase 4 (PDE4) inhibitor that reduces inflammatory mediator production by increasing intracellular cAMP levels.
• GW685698X · GlaxoSmithKline · PDE4 inhibitor · Respiratory/Pulmonology
  GW685698X is a selective inhibitor of phosphodiesterase 4 (PDE4) that reduces inflammatory mediator production by increasing intracellular cAMP levels.
• SPD503 (4 mg) · Shire · Phosphodiesterase 4 (PDE4) inhibitor · Respiratory / Immunology
  SPD503 is a selective phosphodiesterase 4 (PDE4) inhibitor that reduces inflammatory mediator production by increasing intracellular cAMP levels.
• DFN-11 · Dr. Reddy's Laboratories Limited · PDE4 inhibitor · Respiratory/Immunology
  DFN-11 is a selective inhibitor of phosphodiesterase 4 (PDE4) that reduces inflammatory mediator production by suppressing cAMP degradation in immune cells.
• ARQ-151 cream 0.3% · Arcutis Biotherapeutics, Inc. · Phosphodiesterase 4 (PDE4) inhibitor · Dermatology
  ARQ-151 is a topical phosphodiesterase 4 (PDE4) inhibitor that reduces inflammatory cytokine production in skin.
• MP513 · Handok Inc. · PDE4 inhibitor · Respiratory/Pulmonology
  MP513 is a selective inhibitor of phosphodiesterase 4 (PDE4) that reduces inflammatory mediator production by increasing intracellular cAMP levels.
• GI148512 · GlaxoSmithKline · PDE4 inhibitor · Respiratory / Immunology
  GI148512 is a selective inhibitor of phosphodiesterase 4 (PDE4) that reduces inflammatory mediator production by increasing intracellular cAMP levels.
• vehicle of LAS41007 · Almirall, S.A. · PDE4 inhibitor · Respiratory
  LAS41007 is a small molecule inhibitor of the PDE4 enzyme.
• GSK1562902A · GlaxoSmithKline · PDE4 inhibitor · Respiratory/Pulmonology
  GSK1562902A is a selective inhibitor of phosphodiesterase 4 (PDE4) that reduces inflammatory mediator production by increasing intracellular cAMP levels in immune cells.
• (PN-152,243)/ PN-196,444 · Pfizer · Phosphodiesterase 4 (PDE4) inhibitor · Immunology / Respiratory
  PN-152,243/PN-196,444 is a selective inhibitor of phosphodiesterase 4 (PDE4) that reduces inflammatory mediator production by increasing intracellular cAMP levels.
• PF-06410293 · Pfizer · PDE4 inhibitor · Immunology
  PF-06410293 is a selective inhibitor of phosphodiesterase 4 (PDE4) that reduces inflammatory mediator production by increasing intracellular cAMP levels.
• ARQ-151 vehicle cream · Arcutis Biotherapeutics, Inc. · Phosphodiesterase 4 (PDE4) inhibitor · Dermatology
  ARQ-151 is a topical phosphodiesterase 4 (PDE4) inhibitor that reduces inflammatory cytokine production in skin.
• LASW1510 · Almirall, S.A. · PDE4 inhibitor · Immunology / Dermatology
  LASW1510 is a selective inhibitor of phosphodiesterase 4 (PDE4) that reduces inflammatory mediator production in immune cells.
• CD0271 · Galderma R&D · PDE4 inhibitor · Dermatology
  CD0271 is a selective inhibitor of phosphodiesterase 4 (PDE4) that reduces inflammatory mediator production in immune cells.
• GSK523338 · GlaxoSmithKline · PDE4 inhibitor · Respiratory/Pulmonology
  GSK523338 is a selective inhibitor of phosphodiesterase 4 (PDE4) that reduces inflammatory mediator production by increasing intracellular cAMP levels in immune cells.
• SPD503 (1 mg) · Shire · Phosphodiesterase 4 (PDE4) inhibitor · Respiratory / Immunology
  SPD503 is a selective phosphodiesterase 4 (PDE4) inhibitor that reduces inflammatory mediator production by increasing intracellular cAMP levels.
• COV795 · Mallinckrodt · Phosphodiesterase 4 (PDE4) inhibitor · Immunology
  COV795 is a selective inhibitor of phosphodiesterase 4 (PDE4) that reduces inflammatory mediator production by increasing intracellular cAMP levels.
• SPD503 (3 mg) · Shire · Phosphodiesterase 4 (PDE4) inhibitor · Respiratory / Immunology
  SPD503 is a selective phosphodiesterase 4 (PDE4) inhibitor that reduces inflammatory mediator production by increasing intracellular cAMP levels.
• LAS41007 · Almirall, S.A. · Phosphodiesterase 4 (PDE4) inhibitor · Immunology/Dermatology
  LAS41007 is a selective phosphodiesterase 4 (PDE4) inhibitor that reduces inflammatory mediator production by increasing intracellular cAMP levels.
• LASW1835 · Almirall, S.A. · PDE4 inhibitor · Respiratory/Pulmonology
  LASW1835 is a selective inhibitor of phosphodiesterase 4 (PDE4) that reduces inflammatory mediator production by increasing intracellular cAMP levels.
• PL9643 Ophthalmic Solution · ORA, Inc. · Phosphodiesterase 4 (PDE4) inhibitor · Ophthalmology
  PL9643 is a selective phosphodiesterase 4 (PDE4) inhibitor that reduces inflammatory mediator production in ocular tissues.
• PMF104 · Alfasigma S.p.A. · Phosphodiesterase 4 (PDE4) inhibitor · Immunology
  PMF104 is a selective inhibitor of phosphodiesterase 4 (PDE4) that reduces inflammatory mediator production by increasing intracellular cAMP levels.
• GSK 1437173A · GlaxoSmithKline · Phosphodiesterase 4 (PDE4) inhibitor · Respiratory / Immunology
  GSK1437173A is a selective inhibitor of phosphodiesterase 4 (PDE4) that reduces inflammatory mediator production by increasing intracellular cAMP levels.
• RPH-051 · R-Pharm · PDE4 inhibitor · Immunology
  RPH-051 is a selective inhibitor of phosphodiesterase 4 (PDE4) that reduces inflammatory mediator production by increasing intracellular cAMP levels.
• LAS106521 · Almirall, S.A. · Phosphodiesterase 4 (PDE4) inhibitor · Immunology / Dermatology
  LAS106521 is a selective phosphodiesterase 4 (PDE4) inhibitor that reduces inflammatory mediator production by increasing intracellular cAMP levels.
• CD1579 · Galderma R&D · Phosphodiesterase 4 (PDE4) inhibitor · Dermatology
  CD1579 is a selective inhibitor of phosphodiesterase 4 (PDE4) that reduces inflammatory mediator production in immune cells.
• MT1013 · Shaanxi Micot Pharmaceutical Technology Co., Ltd. · PDE4 inhibitor · Immunology
  MT1013 is a small molecule that targets the PDE4 enzyme.
• LAS41005 · Almirall, S.A. · Phosphodiesterase 4 (PDE4) inhibitor · Immunology / Dermatology
  LAS41005 is a selective phosphodiesterase 4 (PDE4) inhibitor that reduces inflammatory mediator production by increasing intracellular cAMP levels.
• LEO 80190 · LEO Pharma · Phosphodiesterase 4 (PDE4) inhibitor · Dermatology
  LEO 80190 is a topical phosphodiesterase 4 (PD4) inhibitor that reduces inflammatory cytokine production in skin.
• TP05 · Tillotts Pharma AG · Phosphodiesterase 4 (PDE4) inhibitor · Dermatology
  TP05 is a topical phosphodiesterase 4 (PD4) inhibitor that reduces inflammatory cytokine production in skin.
• GSK5733584 · GlaxoSmithKline · PDE4 inhibitor · Immunology
  GSK5733584 is a selective inhibitor of phosphodiesterase 4 (PDE4) that reduces inflammatory signaling by increasing intracellular cAMP levels.

Phase 2 pipeline (6)

• Crisaborole ointment 2% BID · Pfizer · Phosphodiesterase 4 (PDE4) inhibitor · Dermatology
  Crisaborole is a phosphodiesterase 4 (PDE4) inhibitor that reduces inflammatory cytokine production in the skin.
• ABT-652 · AbbVie (prior sponsor, Abbott) · Phosphodiesterase 4 (PDE4) inhibitor · Immunology / Respiratory
  ABT-652 is a selective inhibitor of phosphodiesterase 4 (PDE4) that reduces inflammatory mediator production by increasing intracellular cAMP levels.
• AL8326 high dose group · Advenchen Pharmaceuticals, LLC. · PDE4 inhibitor · Immunology/Respiratory
  AL8326 is a selective inhibitor of phosphodiesterase 4 (PDE4) that reduces inflammatory mediator production by increasing intracellular cAMP levels.
• AN2728 Topical Ointment, 0.5% QD · Pfizer · Phosphodiesterase 4 (PDE4) inhibitor · Dermatology
  AN2728 is a phosphodiesterase 4 (PDE4) inhibitor that reduces inflammatory cytokine production in skin cells when applied topically.
• AN2728 Ointment · Pfizer · Phosphodiesterase 4 (PDE4) inhibitor · Dermatology
  AN2728 is a phosphodiesterase 4 (PDE4) inhibitor that reduces inflammatory cytokine production in immune cells.
• GSK217744 · GlaxoSmithKline · PDE4 inhibitor · Immunology
  GSK217744 is a selective inhibitor of phosphodiesterase 4 (PDE4) that reduces inflammatory mediator production by increasing intracellular cAMP levels.

Phase 1 pipeline (2)

• ARQ-151 cream 0.15% · Arcutis Biotherapeutics, Inc. · PDE4 inhibitor · Dermatology
  ARQ-151 is a selective phosphodiesterase 4 (PDE4) inhibitor that modulates inflammatory responses.
• Apremilast Modified Release 13 · Amgen · PDE4 inhibitor · Immunology
  Apremilast is a small molecule inhibitor of phosphodiesterase 4 (PDE4), which leads to increased intracellular levels of cyclic adenosine monophosphate (cAMP).