Microtubules and DNA — Drug Target

All drugs that target Microtubules and DNA — marketed and clinical-stage. Includes 4 drug classes acting on this target.

Drug classes

Taxane and platinum-based chemotherapy · Vinca alkaloid and anthracycline antibiotic · Taxane and platinum-based chemotherapeutic agent · Taxane and platinum-based chemotherapeutic agents

Phase 3 pipeline (3)

• docetaxel - cisplatin - 5-fluorouracil · Gruppo Oncologico del Nord-Ovest · Taxane and platinum-based chemotherapy · Oncology
  Docetaxel inhibits microtubule dynamics, disrupting cell division, while cisplatin induces DNA crosslinks, and 5-fluorouracil inhibits thymidylate synthase.
• Vincristin , Adriamycin, Dexamethasone = VAD · University Hospital, Caen · Vinca alkaloid and anthracycline antibiotic · Oncology
  Vincristine is a vinca alkaloid that inhibits microtubule formation by binding to tubulin, disrupting cell division. Adriamycin is an anthracycline antibiotic that intercalates DNA, inhibiting topoisomerase II and inducing DNA damage. Dexamethasone is a corticosteroid that suppresses inflammation and immune response.
• Taxanes plus Carboplatin · Shanghai Jiao Tong University School of Medicine · Taxane and platinum-based chemotherapeutic agent · Oncology
  Taxanes work by inhibiting microtubule dynamics, disrupting cell division, and inducing apoptosis in cancer cells. Carboplatin works by crosslinking DNA, causing cell death in rapidly dividing cancer cells.

Phase 2 pipeline (1)

• CCRT with weekly docetaxel & cisplatin · Samsung Medical Center · Taxane and platinum-based chemotherapeutic agents · Oncology
  Docetaxel inhibits microtubule dynamics, disrupting cell division, while cisplatin induces DNA crosslinks, causing cell death.