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Vincristin , Adriamycin, Dexamethasone = VAD
Vincristin , Adriamycin, Dexamethasone = VAD is a Vinca alkaloid and anthracycline antibiotic Small molecule drug developed by University Hospital, Caen. It is currently in Phase 3 development for Multiple myeloma, Hodgkin's lymphoma, Non-Hodgkin's lymphoma.
Vincristine is a vinca alkaloid that inhibits microtubule formation by binding to tubulin, disrupting cell division. Adriamycin is an anthracycline antibiotic that intercalates DNA, inhibiting topoisomerase II and inducing DNA damage. Dexamethasone is a corticosteroid that suppresses inflammation and immune response.
Vincristine is a vinca alkaloid that inhibits microtubule formation by binding to tubulin, disrupting cell division. Adriamycin is an anthracycline antibiotic that intercalates DNA, inhibiting topoisomerase II and inducing DNA damage. Dexamethasone is a corticosteroid that suppresses inflammation and immune response. Used for Multiple myeloma, Hodgkin's lymphoma, Non-Hodgkin's lymphoma.
At a glance
| Generic name | Vincristin , Adriamycin, Dexamethasone = VAD |
|---|---|
| Sponsor | University Hospital, Caen |
| Drug class | Vinca alkaloid and anthracycline antibiotic |
| Target | Microtubules and DNA |
| Modality | Small molecule |
| Therapeutic area | Oncology |
| Phase | Phase 3 |
Mechanism of action
Vincristine's mechanism of action is through the inhibition of microtubule formation, which disrupts cell division and leads to cell death. Adriamycin's mechanism of action is through the intercalation of DNA, which inhibits topoisomerase II and induces DNA damage, ultimately leading to cell death. Dexamethasone's mechanism of action is through the suppression of inflammation and immune response, which can help to reduce swelling and alleviate symptoms.
Approved indications
- Multiple myeloma
- Hodgkin's lymphoma
- Non-Hodgkin's lymphoma
Common side effects
- Neutropenia
- Thrombocytopenia
- Anemia
- Nausea and vomiting
- Diarrhea
- Fatigue
Key clinical trials
- Combination Chemotherapy With or Without PSC 833 in Treating Patients With Relapsed or Refractory Multiple Myeloma (PHASE3)
- Combination Chemotherapy and Thalidomide in Treating Patients With Stage I, Stage II, or Stage III Multiple Myeloma (PHASE2)
- Sequential High-dose Dexamethasone and Response Adopted PAD or VAD Induction Chemotherapy Followed by High-dose Chemotherapy With Autologous Stem Cell Transplantation for Newly Diagnosed Multiple Myeloma (PHASE2)
- UARK 89-001 Phase II Study of Intensive "TOTAL THERAPY" For Untreated or Minimally Treated Patients With Multiple Myeloma (PHASE2)
- UARK 98-026 TT II: Multiple Myeloma Evaluating Anti-Angiogenesis With Thalidomide and Post-Transplant Consolidation Chemotherapy (PHASE3)
- Effects of Exercise in Combination With Epoetin Alfa (NA)
- Phase III Randomized Trial of Thalidomide/Dexamethasone Versus Vincristine+Adriamycin+Dexamethasone (VAD) (PHASE3)
- Velcade (Bortezomib), Adriamycin Dexamethasone (PAD) or Vincristine Adriamycin Dexamethasone in Second Line Treatment of Multiple Myeloma (PHASE2)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Vincristin , Adriamycin, Dexamethasone = VAD CI brief — competitive landscape report
- Vincristin , Adriamycin, Dexamethasone = VAD updates RSS · CI watch RSS
- University Hospital, Caen portfolio CI
Frequently asked questions about Vincristin , Adriamycin, Dexamethasone = VAD
What is Vincristin , Adriamycin, Dexamethasone = VAD?
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Who makes Vincristin , Adriamycin, Dexamethasone = VAD?
What drug class is Vincristin , Adriamycin, Dexamethasone = VAD in?
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Related
- Drug class: All Vinca alkaloid and anthracycline antibiotic drugs
- Target: All drugs targeting Microtubules and DNA
- Manufacturer: University Hospital, Caen — full pipeline
- Therapeutic area: All drugs in Oncology
- Indication: Drugs for Multiple myeloma
- Indication: Drugs for Hodgkin's lymphoma
- Indication: Drugs for Non-Hodgkin's lymphoma
- Compare: Vincristin , Adriamycin, Dexamethasone = VAD vs similar drugs
- Pricing: Vincristin , Adriamycin, Dexamethasone = VAD cost, discount & access