HIV-1 reverse transcriptase — Drug Target

All drugs that target HIV-1 reverse transcriptase — marketed and clinical-stage. Includes 7 drug classes acting on this target.

Drug classes

Nucleoside/nucleotide reverse transcriptase inhibitor (NRTI/NtRTI) combination · Non-nucleoside reverse transcriptase inhibitor (NNRTI) · Nucleoside/nucleotide reverse transcriptase inhibitor combination · Non-nucleoside reverse transcriptase inhibitor · Nucleoside reverse transcriptase inhibitor · HIV-1 reverse transcriptase inhibitor · Nucleoside reverse transcriptase inhibitor (NRTI)

Marketed (6)

• Emtricitabine and Tenofovir · Puerto Rico Community Network for Clinical Research on AIDS · Nucleoside/nucleotide reverse transcriptase inhibitor (NRTI/NtRTI) combination · Infectious Disease / Virology
  Emtricitabine and tenofovir are nucleoside/nucleotide reverse transcriptase inhibitors that block HIV replication by inhibiting the enzyme responsible for converting viral RNA into DNA.
• Etravirine (ETR) · ViiV Healthcare · Non-nucleoside reverse transcriptase inhibitor (NNRTI) · Infectious Disease
  Etravirine is a non-nucleoside reverse transcriptase inhibitor (NNRTI) that binds to HIV-1 reverse transcriptase and blocks its ability to convert viral RNA into DNA.
• Emtricitabine / Tenofovir Disoproxil Oral Tablet · University of Chicago · Nucleoside/nucleotide reverse transcriptase inhibitor combination · Infectious Disease / Virology
  Emtricitabine and tenofovir disoproxil are nucleoside/nucleotide reverse transcriptase inhibitors that block HIV replication by inhibiting the enzyme responsible for converting viral RNA into DNA.
• Emtricitabine / Tenofovir Disoproxil Pill · Fundacion IDEAA · Nucleoside/nucleotide reverse transcriptase inhibitor combination · Infectious Disease / Virology
  Emtricitabine and tenofovir disoproxil are nucleoside/nucleotide reverse transcriptase inhibitors that block HIV replication by inhibiting the enzyme responsible for converting viral RNA into DNA.
• Doravirine (DOR) · Walter K. Kraft · Non-nucleoside reverse transcriptase inhibitor (NNRTI) · Infectious Disease / Virology
  Doravirine is a non-nucleoside reverse transcriptase inhibitor (NNRTI) that blocks HIV reverse transcriptase to prevent viral replication.
• Emtricitabine/tenofovir disoproxil fumarate · Advancing Clinical Therapeutics Globally for HIV/AIDS and Other Infections · Nucleoside/nucleotide reverse transcriptase inhibitor (NRTI/NtRTI) combination · Infectious Disease / Virology
  Emtricitabine and tenofovir are nucleoside/nucleotide reverse transcriptase inhibitors that block HIV replication by inhibiting the enzyme responsible for converting viral RNA into DNA.

Phase 3 pipeline (7)

• ART 44 · Laboratoires NEGMA · Non-nucleoside reverse transcriptase inhibitor · Infectious Diseases
  ART 44 is an antiretroviral drug used to treat HIV-1 infection.
• RPV-LA Maintenance Dose · National Institute of Allergy and Infectious Diseases (NIAID) · Non-nucleoside reverse transcriptase inhibitor (NNRTI) · Infectious Disease
  RPV-LA Maintenance Dose is a long-acting formulation of rilpivirine, a non-nucleoside reverse transcriptase inhibitor (NNRTI) that works by blocking the replication of HIV-1.
• RPV-LA Loading Dose · National Institute of Allergy and Infectious Diseases (NIAID) · Non-nucleoside reverse transcriptase inhibitor (NNRTI) · Infectious Disease / Virology
  RPV-LA (rilpivirine long-acting) is a non-nucleoside reverse transcriptase inhibitor (NNRTI) that blocks HIV reverse transcriptase to prevent viral replication.
• efavirenz (drug) · French National Agency for Research on AIDS and Viral Hepatitis · Non-nucleoside reverse transcriptase inhibitor (NNRTI) · Infectious Disease
  Efavirenz is a non-nucleoside reverse transcriptase inhibitor (NNRTI) that works by binding to the reverse transcriptase enzyme, preventing the replication of retroviruses such as HIV.
• ART 50 · Laboratoires NEGMA · Non-nucleoside reverse transcriptase inhibitor · Infectious Diseases
  ART 50 is an antiretroviral medication used to treat HIV-1 infection.
• Rilpivirine (RPV) LA · ViiV Healthcare · Non-nucleoside reverse transcriptase inhibitor (NNRTI) · Infectious Diseases
  Rilpivirine (RPV) LA is a non-nucleoside reverse transcriptase inhibitor (NNRTI) that works by blocking the replication of HIV-1.
• standard treatment in HIV positive · University of Guadalajara · Nucleoside reverse transcriptase inhibitor · Infectious Disease
  This drug works by inhibiting the replication of the HIV virus.

Phase 2 pipeline (3)

• Doravirine, Tenofovir, Lamivudine - Open-Label · Merck Sharp & Dohme LLC · HIV-1 reverse transcriptase inhibitor · Infectious Diseases
  Doravirine is an HIV-1 non-nucleoside reverse transcriptase inhibitor (NNRTI), while Tenofovir and Lamivudine are HIV-1 nucleotide reverse transcriptase inhibitors (NtRTIs) and nucleoside reverse transcriptase inhibitors (NRTIs), respectively.
• ATRIPLA^TM · Merck Sharp & Dohme LLC · Non-nucleoside reverse transcriptase inhibitor · Infectious Disease
  Non-nucleoside reverse transcriptase inhibitor
• ETV or TDF · Tasly Tianjin Biopharmaceutical Co., Ltd. · Nucleoside reverse transcriptase inhibitor (NRTI) · Infectious Disease
  Inhibits viral replication