Last reviewed 2026-04-23 · How we verify

ETV or TDF

Inhibits viral replication

Inhibits viral replication Used for HIV-1 infection.

At a glance

Mechanism of action

ETV is a nucleoside reverse transcriptase inhibitor (NRTI) that works by inhibiting the replication of viral DNA.

Approved indications

• HIV-1 infection

Common side effects

• Nausea
• Diarrhea
• Fatigue

Key clinical trials

• Entecavir Resistance-Associated Mutations in Chronic HBV Patients in Turkey (STREAM Study)
• Stopping Antiviral Treatment in Chronic Hepatitis B
• A Study to Investigate Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of RO7565020 in Healthy Participants and in Participants With Chronic Hepatitis B Virus Infection (PHASE1)
• A Multi-dose Study of ARC-520 in Patients With Hepatitis B 'e' Antigen (HBeAg) Negative, Chronic Hepatitis B Virus (HBV) Infection (PHASE2)
• Extension Study of the Safety and Efficacy of Multi-dose Intravenous ARC-520 in Patients With Chronic Hepatitis B (HBV) Infection (PHASE2)
• Study of ARC-520 With or Without Other Drugs Used in the Treatment of Chronic Chronic Hepatitis B Virus (HBV) (PHASE2)
• A Multi-dose Study of ARC-520 in Patients With Hepatitis B 'e' Antigen (HBeAg) Positive, Chronic Hepatitis B Virus Infection (PHASE2)
• A Study of ARC-521 Injection in Normal Adult Volunteers and Patients With Chronic Hepatitis B (CHB) (PHASE1)

Primary sources

Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.

Competitive intelligence

For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:

• ETV or TDF CI brief — competitive landscape report
• ETV or TDF updates RSS · CI watch RSS
• Tasly Tianjin Biopharmaceutical Co., Ltd. portfolio CI