Ergosterol — Drug Target

All drugs that target Ergosterol — marketed and clinical-stage. Includes 2 drug classes acting on this target.

Drug classes

Polyene macrolide antifungal · Polyene antifungal

Marketed (4)

• Nystatin 10000U/ml · Riyadh Colleges of Dentistry and Pharmacy · Polyene macrolide antifungal · Infectious Disease
  Nystatin binds to ergosterol in fungal cell membranes, creating pores that cause leakage and cell death.
• Nystatin oral suspension · Advancing Clinical Therapeutics Globally for HIV/AIDS and Other Infections · Polyene macrolide antifungal · Infectious Disease
  Nystatin binds to ergosterol in fungal cell membranes, creating pores that cause leakage and cell death.
• Liposomal Amphotericin B · Taiwan Liposome Company · Polyene antifungal · Infectious Disease
  Liposomal amphotericin B binds to ergosterol in fungal cell membranes, creating pores that disrupt membrane integrity and cause fungal cell death.
• Amphotericin B Deoxycholate · Drugs for Neglected Diseases · Polyene antifungal · Infectious Diseases
  Amphotericin B binds to ergosterol in fungal cell membranes, creating pores that disrupt membrane integrity and cause cell death.

Phase 3 pipeline (4)

• Conventional amphotericin B · Pfizer · Polyene antifungal · Infectious Disease
  Amphotericin B binds to ergosterol in fungal cell membranes, creating pores that disrupt membrane integrity and lead to cell death.
• Amphotericin B liposomes · CSPC ZhongQi Pharmaceutical Technology Co., Ltd. · Polyene antifungal · Infectious Disease
  Amphotericin B disrupts fungal cell membranes by binding to ergosterol, causing leakage of cellular contents and cell death.
• Amphotericin B Lipid emulsion · Bharat Serums and Vaccines Limited · Polyene antifungal · Infectious Disease
  Amphotericin B binds to ergosterol in fungal cell membranes, creating pores that disrupt membrane integrity and cause cell death.
• Group 3: Liposomal amphotericin B · Fundacion Nacional de Dermatologia · Polyene antifungal · Infectious Disease
  Liposomal amphotericin B binds to ergosterol in fungal cell membranes, disrupting membrane integrity and causing cell death.

Phase 2 pipeline (1)

• High dose TSO · Dr. Falk Pharma GmbH · Polyene antifungal · Infectious Disease
  Treats Cryptococcal meningitis by inhibiting the cell wall synthesis of Cryptococcus neoformans

Phase 1 pipeline (1)

• Amphotericin B liposome for injection · CSPC Zhongnuo Pharmaceutical (Shijiazhuang) Co., Ltd. · Polyene antifungal · Infectious Disease
  Interferes with fungal cell membrane function