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High dose TSO
Treats Cryptococcal meningitis by inhibiting the cell wall synthesis of Cryptococcus neoformans
Treats Cryptococcal meningitis by inhibiting the cell wall synthesis of Cryptococcus neoformans Used for Cryptococcal meningitis.
At a glance
| Generic name | High dose TSO |
|---|---|
| Sponsor | Dr. Falk Pharma GmbH |
| Drug class | Polyene antifungal |
| Target | Ergosterol |
| Modality | Small molecule |
| Therapeutic area | Infectious Disease |
| Phase | Phase 2 |
Mechanism of action
High dose TSO is a form of liposomal amphotericin B, which is a polyene antifungal medication. It works by binding to ergosterol in the fungal cell membrane, leading to cell lysis and death.
Approved indications
- Cryptococcal meningitis
Common side effects
- Nausea
- Vomiting
- Diarrhea
- Abdominal pain
- Headache
- Fatigue
- Rash
- Hypersensitivity reaction
- Anaphylaxis
Key clinical trials
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |