What are Polyene antifungal drugs?

Polyene antifungal drugs are pharmacologic agents that share a common mechanism (typically targeting Ergosterol). 2 are currently marketed, with 8 more in clinical development.

What are the marketed Polyene antifungal drugs?

Marketed Polyene antifungal drugs include Liposomal Amphotericin B, Amphotericin B Deoxycholate.

Polyene antifungal

2 marketed 6 in Phase 3 1 in Phase 2 1 in Phase 1

This page covers all Polyene antifungal drugs tracked by Drug Landscape: marketed products and active clinical-stage compounds, targeting Ergosterol, Ergosterol (fungal cell membrane sterol), Sterol component of fungal cell membranes.

Targets

Ergosterol · Ergosterol (fungal cell membrane sterol) · Sterol component of fungal cell membranes

Marketed (2)

Liposomal Amphotericin B · Taiwan Liposome Company · Infectious Disease
Liposomal amphotericin B binds to ergosterol in fungal cell membranes, creating pores that disrupt membrane integrity and cause fungal cell death.
Amphotericin B Deoxycholate · Drugs for Neglected Diseases · Infectious Diseases
Amphotericin B binds to ergosterol in fungal cell membranes, creating pores that disrupt membrane integrity and cause cell death.

Phase 3 pipeline (6)

Group 3: Liposomal amphotericin B · Fundacion Nacional de Dermatologia · Infectious Disease
Liposomal amphotericin B binds to ergosterol in fungal cell membranes, disrupting membrane integrity and causing cell death.
L-AmB standard dose · Federal University of Health Science of Porto Alegre · Infectious Disease
L-AmB (liposomal amphotericin B) binds to ergosterol in fungal cell membranes, creating pores that disrupt membrane integrity and lead to cell death.
Amphotericin B liposomes · CSPC ZhongQi Pharmaceutical Technology Co., Ltd. · Infectious Disease
Amphotericin B disrupts fungal cell membranes by binding to ergosterol, causing leakage of cellular contents and cell death.
Amphotericin B Lipid emulsion · Bharat Serums and Vaccines Limited · Infectious Disease
Amphotericin B binds to ergosterol in fungal cell membranes, creating pores that disrupt membrane integrity and cause cell death.
Conventional amphotericin B · Pfizer · Infectious Disease
Amphotericin B binds to ergosterol in fungal cell membranes, creating pores that disrupt membrane integrity and lead to cell death.
inhaled Ambisome® · Poitiers University Hospital · Infectious Diseases
Amphotericin B, the active component of Ambisome, binds to the sterol component of fungal cell membranes, causing cell lysis and death.

Phase 2 pipeline (1)

High dose TSO · Dr. Falk Pharma GmbH · Infectious Disease
Treats Cryptococcal meningitis by inhibiting the cell wall synthesis of Cryptococcus neoformans

Phase 1 pipeline (1)

Amphotericin B liposome for injection · CSPC Zhongnuo Pharmaceutical (Shijiazhuang) Co., Ltd. · Infectious Disease
Interferes with fungal cell membrane function