DPP-4 — Drug Target

All drugs that target DPP-4 — marketed and clinical-stage. Includes 5 drug classes acting on this target.

Drug classes

DPP-4 inhibitor · DPP-4 inhibitor and biguanide combination · DPP-4 inhibitor and biguanide · DPP-IV inhibitor · DPP-4 inhibitor and sulfonylurea

Marketed (1)

• Tang · Louisville Metabolic and Atherosclerosis Research Center · DPP-4 inhibitor · Diabetes
  Tang is a medication used to treat type 2 diabetes by lowering blood sugar levels.

Phase 3 pipeline (13)

• Placebo matching with Saxagliptin · AstraZeneca · DPP-4 inhibitor · Diabetes
  Saxagliptin is a dipeptidyl peptidase-4 (DPP-4) inhibitor, which increases the levels of incretin hormones, thereby enhancing glucose-dependent insulin secretion.
• Nordilet® · Cinnagen · DPP-4 inhibitor · Diabetes
  Nordilet is a dipeptidyl peptidase-4 (DPP-4) inhibitor, which increases the levels of incretin hormones to enhance glucose-dependent insulin secretion.
• Matching Placebo to Sita/Met FDC · Merck Sharp & Dohme LLC · DPP-4 inhibitor and biguanide combination · Diabetes
  Sita/Met FDC combines sitagliptin, a dipeptidyl peptidase-4 inhibitor, with metformin, a biguanide, to improve glycemic control in patients with type 2 diabetes.
• sitagliptin (MK0431) · Merck Sharp & Dohme LLC · DPP-4 inhibitor · Diabetes
  Sitagliptin works by inhibiting the enzyme dipeptidyl peptidase-4 (DPP-4), which is involved in the inactivation of incretin hormones.
• sitagliptin OR saxagliptin · University of Sao Paulo General Hospital · DPP-4 inhibitor · Diabetes
  Sitagliptin and saxagliptin are dipeptidyl peptidase-4 (DPP-4) inhibitors, which increase the levels of incretin hormones to enhance glucose-dependent insulin secretion.
• Placebo Evogliptin · Eurofarma Laboratorios S.A. · DPP-4 inhibitor · Diabetes
  Evogliptin is a dipeptidyl peptidase-4 (DPP-4) inhibitor.
• oral sitagliptin supplementation · Ain Shams University · DPP-4 inhibitor · Diabetes
  Sitagliptin works by inhibiting the enzyme dipeptidyl peptidase-4 (DPP-4), which breaks down incretin hormones.
• Sentagliptin Phosphate - single dose · Second Affiliated Hospital of Soochow University · DPP-4 inhibitor · Diabetes
  Sentagliptin phosphate is a dipeptidyl peptidase-4 (DPP-4) inhibitor, which increases the levels of incretin hormones to enhance glucose-dependent insulin secretion.
• Placebo to sitagliptin plus metformin · Merck Sharp & Dohme LLC · DPP-4 inhibitor and biguanide · Diabetes
  Sitagliptin plus metformin works by inhibiting dipeptidyl peptidase-4 (DPP-4) and reducing glucose production in the liver, and increasing insulin secretion.
• Placebo (Saxagliptin) · AstraZeneca · DPP-4 inhibitor · Diabetes
  Saxagliptin is a dipeptidyl peptidase-4 (DPP-4) inhibitor, which works by increasing the levels of incretin hormones to stimulate the release of insulin and decrease the release of glucagon.
• Sitagliptin plus metformin · Merck Sharp & Dohme LLC · DPP-4 inhibitor and biguanide · Diabetes
  Sitagliptin, a dipeptidyl peptidase-4 (DPP-4) inhibitor, increases incretin levels, enhancing glucose-dependent insulin secretion, and metformin, a biguanide, decreases hepatic glucose production and increases insulin sensitivity.
• Teneligliptin Placebo Oral Tablet · Handok Inc. · DPP-4 inhibitor · Diabetes
  Teneligliptin is a dipeptidyl peptidase-4 (DPP-4) inhibitor that increases the levels of incretin hormones, enhancing glucose-dependent insulin secretion.
• Placebo to Linagliptin · LG Life Sciences · DPP-4 inhibitor · Diabetes
  Linagliptin is a dipeptidyl peptidase-4 (DPP-4) inhibitor, which increases the levels of incretin hormones, thereby enhancing glucose-dependent insulin secretion.

Phase 2 pipeline (3)

• DPP-IV Inhibitor · Hoffmann-La Roche · DPP-IV inhibitor · Diabetes
  DPP-IV inhibitors block the action of dipeptidyl peptidase-4, an enzyme that breaks down incretin hormones, thereby increasing incretin levels and enhancing glucose-dependent insulin secretion.
• ESL Tutti-Frutti taste · Bial - Portela C S.A. · DPP-4 inhibitor · Diabetes
  ESL works by inhibiting the enzyme dipeptidyl peptidase-4 (DPP-4).
• Alogliptin and glimepiride · Takeda · DPP-4 inhibitor and sulfonylurea · Diabetes
  Alogliptin is a dipeptidyl peptidase-4 (DPP-4) inhibitor, and glimepiride is a sulfonylurea that stimulates insulin release.