CD47 — Drug Target

All drugs that target CD47 — marketed and clinical-stage. Includes 12 drug classes acting on this target.

Drug classes

monoclonal antibody · CD47/SIRPα inhibitor · Radiopharmaceutical · SIRPα inhibitor · CD47 inhibitor · CD47 antibody · Checkpoint inhibitor · CD47-SIRPα inhibitor · Targeted alpha-particle therapy · CD47/SIRPα axis inhibitor · CD47/SIRPα modulator · CD47-targeting monoclonal antibody

Phase 3 pipeline (10)

• MB-102 DMID · Hangzhou Zhongmei Huadong Pharmaceutical Co., Ltd. · monoclonal antibody · Oncology
  MB-102 DMID is a monoclonal antibody targeting CD47.
• mini CYVE, without 3 maintenance courses · Gustave Roussy, Cancer Campus, Grand Paris · CD47/SIRPα inhibitor · Oncology
  mini CYVE targets the CD47/SIRPα axis to promote phagocytosis of cancer cells.
• [68Ga]Ga-PentixaFor · Nantes University Hospital · Radiopharmaceutical · Oncology
  Ga-PentixaFor is a radiopharmaceutical that targets the CD47/SIRPα axis.
• RNF · Merck KGaA, Darmstadt, Germany · CD47/SIRPα inhibitor · Oncology
  RNF is a small molecule targeting the CD47/SIRPα axis.
• Treatment Choice (TC) · Astex Pharmaceuticals, Inc. · SIRPα inhibitor · Oncology
  Treatment Choice (TC) is a small molecule that targets the CD47/SIRPα axis.
• Open single period A140 · Sichuan Kelun-Biotech Biopharmaceutical Co., Ltd. · CD47 inhibitor · Oncology
  A140 is a monoclonal antibody targeting CD47.
• HP-802-247 · Healthpoint · CD47 antibody · Oncology
  HP-802-247 is a monoclonal antibody targeting CD47.
• MB-102 OMID · Hangzhou Zhongmei Huadong Pharmaceutical Co., Ltd. · CD47 inhibitor · Oncology
  MB-102 OMID is a monoclonal antibody targeting CD47.
• TAK-667 · Takeda · CD47 antibody · Oncology
  TAK-667 is a CD47 antibody that works by blocking the interaction between CD47 and SIRPα on macrophages, thereby promoting phagocytosis of tumor cells.
• TBI-1301 · Takara Bio Inc. · CD47 antibody · Oncology
  TBI-1301 is a monoclonal antibody targeting CD47.

Phase 2 pipeline (18)

• M-CENK · ImmunityBio, Inc. · Checkpoint inhibitor · Oncology
  M-CENK is a cancer immunotherapy that targets the CD47/SIRPα axis.
• CC-97540 · Juno Therapeutics, Inc., a Bristol-Myers Squibb Company · CD47 inhibitor · Oncology
  CC-97540 is a monoclonal antibody targeting CD47.
• BT5528 · BicycleTx Limited · CD47/SIRPα inhibitor · Oncology
  BT5528 is a small molecule inhibitor of the CD47/SIRPα axis.
• CTC-501 · Chase Therapeutics Corporation · CD47-SIRPα inhibitor · Oncology
  CTC-501 is a CD47-SIRPα inhibitor, which works by blocking the interaction between CD47 and SIRPα on the surface of immune cells, thereby enhancing the immune system's ability to recognize and destroy cancer cells.
• 131-I-TM-601 · TransMolecular · Targeted alpha-particle therapy · Oncology
  131-I-TM-601 is a targeted alpha-particle therapy that selectively targets and destroys cancer cells.
• BAT4406F Injection · Bio-Thera Solutions · CD47 antibody · Oncology
  BAT4406F Injection is a monoclonal antibody targeting CD47.
• BRC-001 · City of Hope Medical Center · CD47/SIRPα axis inhibitor · Oncology
  BRC-001 is a small molecule targeting the CD47/SIRPα axis.
• AK131 · Akeso · CD47/SIRPα modulator · Oncology
  AK131 is a small molecule targeting the CD47/SIRPα axis to modulate the immune system.
• ADX415 · Addrenex Pharmaceuticals, Inc. · CD47 inhibitor · Oncology
  ADX415 is a monoclonal antibody targeting CD47.
• BMS-954561 · Bristol-Myers Squibb · CD47/SIRPα axis inhibitor · Oncology
  BMS-954561 is a small molecule that targets the CD47/SIRPα axis.
• ADX-914 · Q32 Bio Inc. · CD47 inhibitor · Oncology
  ADX-914 is a monoclonal antibody targeting CD47.
• AGMB-129 · Agomab Spain S.L. · monoclonal antibody · Oncology
  AGMB-129 is an anti-CD47 monoclonal antibody.
• Ag-D-CIK · Shenzhen Hornetcorn Bio-technology Company, LTD · CD47 antibody · Oncology
  Ag-D-CIK is a monoclonal antibody that targets CD47.
• Cellgram-ED · Pharmicell Co., Ltd. · CD47/SIRPα inhibitor · Oncology
  Cellgram-ED is a small molecule that targets the CD47/SIRPα axis to modulate the immune response.
• GL-0817 · Gliknik Inc. · monoclonal antibody · Oncology
  GL-0817 is an anti-CD47 monoclonal antibody.
• AK117 · Akeso · CD47/SIRPα axis inhibitor · Oncology
  AK117 is a small molecule targeting the CD47/SIRPα axis.
• CBT-001 single dose · Cloudbreak Therapeutics, LLC · CD47/SIRPα axis inhibitor · Oncology
  CBT-001 is a small molecule that targets the CD47/SIRPα axis.
• BIIB091 · Biogen · CD47-targeting monoclonal antibody · Oncology
  BIIB091 is a monoclonal antibody targeting CD47.

Phase 1 pipeline (1)

• AK112, Cadonilimab, nab-paclitaxel, gemcitabine · Akeso · CD47 antibody · Oncology
  CD47 antibody