Radiopharmaceutical

This page covers all Radiopharmaceutical drugs tracked by Drug Landscape: marketed products and active clinical-stage compounds, targeting Bone cells, Somatostatin receptors (SSTRs) on neuroendocrine tumor cells, CD47.

Targets

Bone cells · Somatostatin receptors (SSTRs) on neuroendocrine tumor cells · CD47 · Bone hydroxyapatite (via HEDP bisphosphonate moiety) · Choline transporter · PSMA · Sodium-iodide symporter (NIS) · Adrenocortical tissue (cholesterol metabolism pathway) · Glucose transporter

Marketed (2)

• Radium-223 · Pfizer · Oncology · 400
• Ga-68-DOTATOC · Weill Medical College of Cornell University · Oncology

Phase 3 pipeline (8)

• [68Ga]Ga-PentixaFor · Nantes University Hospital · Oncology
  Ga-PentixaFor is a radiopharmaceutical that targets the CD47/SIRPα axis.
• Rhenium-188-HEDP · Amsterdam UMC, location VUmc · Oncology
  Rhenium-188-HEDP is a radiopharmaceutical that localizes to areas of increased bone metabolism and delivers beta radiation directly to bone lesions for pain palliation and potential therapeutic benefit.
• Sodium Fluoride F-18 Injection · HTA Co., Ltd. · Oncology
  Sodium Fluoride F-18 Injection is a radiopharmaceutical used for diagnostic imaging.
• Radiopharmaceutical 18F-Fluorocholine · ITEL Telecomunicazioni Srl · Oncology
  18F-Fluorocholine is a radiopharmaceutical that accumulates in cells with high choline uptake, allowing for imaging of cancer cells.
• rhPSMA-7.3 (18F) Injection · Blue Earth Diagnostics · Oncology
  rhPSMA-7.3 (18F) Injection is a radiopharmaceutical that targets prostate-specific membrane antigen (PSMA) for diagnostic imaging.
• I131 · Gustave Roussy, Cancer Campus, Grand Paris · Oncology
  Iodine-131 is a radioactive isotope that emits beta particles to destroy thyroid cancer cells and other iodine-avid malignancies.
• [68Ga]CBP8 PET/MRI · Brigham and Women's Hospital · Oncology
  This drug is a radiopharmaceutical that targets the PSMA protein.
• I-131 Iodocholesterol · M.D. Anderson Cancer Center · Oncology
  I-131 Iodocholesterol is a radiolabeled cholesterol analog that localizes to adrenocortical tissue and delivers targeted radiation for imaging and therapeutic purposes in adrenocortical carcinoma.

Phase 2 pipeline (3)

• 131I · Genzyme, a Sanofi Company · Oncology
  Iodine-131 is a radioactive isotope that emits beta particles to destroy thyroid tissue and thyroid cancer cells.
• Fludeoxyglucose PET CT · Michael C Roarke, MD · Oncology
  A positron-emitting glucose analog that accumulates in cancer cells, allowing for PET imaging.
• 99m-TC-PSMA-I&S · IRCCS San Raffaele · Oncology
  99m-TC-PSMA-I&S is a radiopharmaceutical that targets prostate-specific membrane antigen (PSMA) for diagnostic imaging of prostate cancer.