Asparagine — Drug Target

All drugs that target Asparagine — marketed and clinical-stage. Includes 3 drug classes acting on this target.

Drug classes

Enzyme · Enzyme (asparagine depleting agent) · Enzyme (asparaginase)

Marketed (2)

• recombinant asparaginase · medac GmbH · Enzyme · Oncology
  Recombinant asparaginase depletes the amino acid asparagine from the bloodstream, starving asparagine-dependent leukemic cells of an essential nutrient required for protein synthesis.
• Erwinia asparaginase · Andrew E. Place, MD · Enzyme · Oncology
  Erwinia asparaginase depletes the amino acid asparagine in the bloodstream, starving leukemic cells that cannot synthesize their own asparagine.

Phase 3 pipeline (4)

• L-ASP · First Affiliated Hospital of Zhejiang University · Enzyme (asparagine depleting agent) · Oncology
  L-ASP (L-asparaginase) depletes the amino acid asparagine in leukemic cells, which cannot synthesize their own asparagine and thus undergo apoptosis.
• PEG Asparaginase at six weeks interval · Rigshospitalet, Denmark · Enzyme (asparagine depleting agent) · Oncology
  PEG Asparaginase depletes the amino acid asparagine in the bloodstream, starving leukemic cells that cannot synthesize their own asparagine.
• PEG Asparaginase at two weeks interval · Rigshospitalet, Denmark · Enzyme (asparaginase) · Oncology
  PEG Asparaginase depletes the amino acid asparagine in the bloodstream, starving leukemic cells that cannot synthesize their own asparagine.
• E. coli Asparaginase · Dana-Farber Cancer Institute · Enzyme · Oncology
  E. coli asparaginase depletes the amino acid asparagine in the bloodstream, starving leukemic cells that cannot synthesize their own asparagine.