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Vonoprazan-Amoxicillin with Berberine
This combination uses vonoprazan to suppress gastric acid, amoxicillin to kill H. pylori bacteria, and berberine as an adjunctive antimicrobial and anti-inflammatory agent for H. pylori eradication.
This combination uses vonoprazan to suppress gastric acid, amoxicillin to kill H. pylori bacteria, and berberine as an adjunctive antimicrobial and anti-inflammatory agent for H. pylori eradication. Used for Helicobacter pylori infection eradication.
At a glance
| Generic name | Vonoprazan-Amoxicillin with Berberine |
|---|---|
| Sponsor | Nanjing First Hospital, Nanjing Medical University |
| Drug class | H. pylori eradication therapy (combination: proton pump inhibitor alternative + beta-lactam antibiotic + herbal antimicrobial) |
| Target | H+/K+-ATPase (vonoprazan); bacterial cell wall (amoxicillin); multiple H. pylori targets (berberine) |
| Modality | Small molecule |
| Therapeutic area | Gastroenterology / Infectious Disease |
| Phase | FDA-approved |
Mechanism of action
Vonoprazan is a potassium-competitive acid blocker that inhibits the H+/K+-ATPase pump to reduce gastric acid secretion, creating an optimal pH environment for amoxicillin efficacy against H. pylori. Amoxicillin is a beta-lactam antibiotic that disrupts bacterial cell wall synthesis. Berberine, a plant alkaloid, provides additional antimicrobial activity against H. pylori and may enhance treatment efficacy through anti-inflammatory mechanisms.
Approved indications
- Helicobacter pylori infection eradication
Common side effects
- Diarrhea
- Nausea
- Abdominal discomfort
- Headache
- Taste disturbance
Key clinical trials
- Eradication of Helicobacter Pylori Improves Metabolic Syndrome Through Modulation of Gut Microbiota. (PHASE4)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
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